I have suffered with depression since I was 18. For the first couple years I only did therapy, then I started taking Prozac, because it was the drug at the time, it had only been on the market about a month.It didn't work, made things worse. Over the years I switched between taking nothing and trying what the latest drug was. Nothing worked for long. I could take something for 4-6 months and it would just stop working overnight, no rhyme or reason. I would be at work and just lose all interest in everything. Someone could have dropped $10 million on my lap and I wouldn't have given a damn. Its f'ing miserable to be that way. Imagine feeling like you are hollow, nothing matters and death becomes something to focus on because you have no reason to stay around. Every minute alive is like someone pouring salt in your wounds.
Then about 4 years ago I started taking the drug effexor (venlafaxine). Within two weeks I was ready to take on life again. It was like someone flipped a switch and I saw things in my life in ways that I couldn't see them before. I worry now that one day effexor will stop working like the others did, but so far their is not indication of that. Now the bad side . Effexor is like quitting cocaine. Some addicts have said that they would rather quit heroin than try to stop taking effexor. The longer you take it the worse the effects of stopping become. I have had a few times where I ran out . I thought it will just be two days then I can get a refill and all will be okay till then. Man was I wrong. By the second day I couldn't sleep, I was nauseated, my vision blurred, headaches and sweating. Changing what I was looking at in a room would cause shocks inside my head. Two hours after taking the drug again all those effects were gone. I know of a girl who tried suicide because she missed two doses. She said everything was fine and so she thought she could just quit taking it, then two days later overdosed and was in the ER.
I am grateful to the drug company that makes effexor and other drugs, but I am pissed they did not warn me or others about the danger of missing doses until after we were already taking the drugs. It is like a crack dealer selling crack, hooking people, then telling them "oh, did I mention, its a bitch to stop?"