FO3 was a bit weird for me when I first got it. It would crash, have weird glitches akin to script triggers not working, etc. I shelved it, formatted my system somewhere along the lines, and came back later on to it working perfectly. New Vegas hasn't given me any problems except one crash, though I haven't tried it on my new system.
Thought about getting Bioshock 2, but I couldn't bring myself to finish the first one. It was System Shock with a different skin, so I lost interest since I played System Shock/2 WAY too much.
I did, however, pick up RE5. It was a little more than I wanted to pay given the age of the game (relative to it's original release), but it's been a while since I've played an RE game. I'm also hoping the change in playstyle will keep it fresh.
About the only other game I'm looking forward to is Divinity 2 DK going on sale for more than the publisher's pack discount. And maybe Borderland's DLC since I haven't gotten Claptrap's Revolution yet, and don't want to pay $10 for it.