NON_POLITICAL China Coronavirus THREAD

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Ichinisan

Ichinisan

Lifer
Oct 9, 2002
28,298
1,235
136
Guys, testing a vaccine is different in some ways from testing a chemical drug. I even see some of you unironically call the vaccine a "drug" -???

An arbitrary 2 months is a bit excessive when people are dying.
 
Brainonska511

Brainonska511

Lifer
Dec 10, 2005
29,616
15,177
136
Ichinisan said:
Guys, testing a vaccine is different in some ways from testing a chemical drug. I even see some of you unironically call the vaccine a "drug" -???

An arbitrary 2 months is a bit excessive when people are dying.
Click to expand...
A vaccine is a drug/biologic, legally and technically speaking. Taking it only once or twice doesn't change that.

Asking for 2 months of safety data (for the median number of patients) is also not arbitrary. Historically, certain serious, and rare adverse events of interest crop up in this window. It's important to get it right and ensure you can approve and release a product that people are confident in tbe safety of.
 
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K1052

K1052

Elite Member
Aug 21, 2003
53,756
48,430
136
CZroe said:
Which is what Phase III is supposed to determine/prove... not whatever delay we can concoct after Phase III concludes.
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Not really. The trial protocols as designed are pretty generous (too generous a lot of scientists argue) with the symptoms that can be counted in the placebo group. Arguably they could meet the earlier standards the FDA put out for emergency approval. Going back and requiring a few severe COVID cases is good and unlikely to meaningfully delay vaccine introduction.
 
K1052

K1052

Elite Member
Aug 21, 2003
53,756
48,430
136
Eli Lilly has submitted for an EUA on their antibody treatments.

They had some positive results but I can think of an event that's spurred them on.
 
Svnla

Svnla

Lifer
Nov 10, 2003
17,986
1,388
126
The World Bank estimates at least 115 million of poor people worldwide will be in extreme poverty, could even face starvation because of the virus.
 
P

pmv

Lifer
May 30, 2008
15,142
10,043
136
Is this good news (because it suggests immunity-through-infection may be more widespread/achievable than thought) or is it bad news (because it means it's going to be very hard to control the spread in future and protect the vulnerable, unless we constantly test everybody)?


www.theguardian.com

Covid: more than 80% of positive UK cases in study had no core symptoms

ONS survey said 86.1% of people between April and June had none of the virus’ main symptoms
www.theguardian.com www.theguardian.com
 
Scarpozzi

Scarpozzi

Lifer
Jun 13, 2000
26,392
1,780
126
snoopy7548 said:
His tan is looking fierce. I pasted the picture into Paint and took samples of his face and hands. Here's the difference:

View attachment 31299
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Far fewer pixels to work with on those tiny little hands.

I think he has facial swelling from the steroids, but he may have bruising on his right cheek. His skin color looks pretty bad. That spray tan looks like it was applied to a vampire.
 
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CZroe

CZroe

Lifer
Jun 24, 2001
24,195
857
126
Maybe we have it all wrong: Trump uses orange to hide a dark skin condition and it's wearing off now that his airbrush guy can't come close. ;)
 
CZroe

CZroe

Lifer
Jun 24, 2001
24,195
857
126
K1052 said:
Regeneron files for EUA on their antibody combo treatement

While I think antibody therapies are likely to be pretty helpful the relatively low number of doses available compared to daily US cases, which are escalating, is going to limit the impact.

https://twitter.com/x/status/1314011763713683456
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I think that's the wrong comparison to make. Though Trump wants us to think it's for everyone, it's really only needed for severe cases and people who can't form their own antibodies.
 
BarkingGhostar

BarkingGhostar

Diamond Member
Nov 20, 2009
8,410
1,617
136
I'm still thinking of opening a funeral home franchise business. What say you? And no, its not why I take the position on spiking the curve, but that'd surely help business.
 
K1052

K1052

Elite Member
Aug 21, 2003
53,756
48,430
136
CZroe said:
I think that's the wrong comparison to make. Though Trump wants us to think it's for everyone, it's really only needed for severe cases and people who can't form their own antibodies.
Click to expand...

You want to give antibodies before the condition is severe which is when they'll do the most good. I doubt they are going to pull blood on everybody who rolls up to the ER with multiple comorbitities to peek at their antibody levels, especially if they are older. A call is going to be made based on age and condition. If hospitalizations surge again as expected supply is going to be an issue.
 
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K1052

K1052

Elite Member
Aug 21, 2003
53,756
48,430
136
This is not the way to represent the situation. So far the only vaccines likely so see approval soon are the mRNA vaccines which the CDC planning say 45M cumulative doses max by EOY. I have not seen production estimates for either beyond that but call me real skeptical they can churn out over 600M doses by March. AstraZeneca is still stuck in the US so that one isn't going anywhere soon even if they have a ton of doses made. J&J is up next but probably won't have results until early next year.


https://twitter.com/x/status/1314214967030104066
 
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CZroe

CZroe

Lifer
Jun 24, 2001
24,195
857
126
K1052 said:
You want to give antibodies before the condition is severe which is when they'll do the most good. I doubt they are going to pull blood on everybody who rolls up to the ER with multiple comorbitities to peek at their antibody levels, especially if they are older. A call is going to be made based on age and condition. If hospitalizations surge again as expected supply is going to be an issue.
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Right, but they can give it to people with known immunocompromises and people at particular risk, like nursing home patients. They obviously didn't wait for Trump to get severe before giving it to him. The point is to give it as soon as someone risky tests positive so their immune system gets a head start... not to wait and see if they produce antibodies. So, yeah, you're right: testing for antibodies is not the way to go.

I should have said/meant to say it was only for POTENTIALLY severe cases and people with knowingly-suppressed antibody production.
 
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local

local

Golden Member
Jun 28, 2011
1,852
517
136
K1052 said:
Dose 2 is supposed to be the fun one.
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That's what I understand as well. The person next to me answering questions had different side effects, mostly fever, and the second dose was not as bad as the first. They are having their one month visit.

So one real world account vs multiple internet stories. I guess I will find out.
 
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snoopy7548

snoopy7548

Diamond Member
Jan 1, 2005
8,301
5,384
146
BarkingGhostar said:
I'm still thinking of opening a funeral home franchise business. What say you? And no, its not why I take the position on spiking the curve, but that'd surely help business.
Click to expand...

@highland145 should be able to help you out. He lives next to a funeral home, so he knows the business, and he provides loans at competitive prices.
 
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