****Last Man on Earth Spoilers****
Last night I watched both Last Man on Earth and I Am Legend. Last Man was definitely the movie I watched many years ago and is a movie worth watching, but it was quite different than I Am Legend, but with some similarities. Both main characters had a Wife and Daughter, both were Researchers looking for the cure, both buried the dog although in Last Man the dog comes in the middle of the movie and only lives with the main character for half a day before dying, in both there's a woman except in Last Man the woman is actually infected but has a drug that needs taken on a regular basis that keeps her from reverting to full infection(in fact she once had full infection), both discover a cure but end up dying except in Last Man the Cure ends up being destroyed.
The differences: All animals are infected/killed by the Virus in Last Man, the Infected are rather slow and cumbersome in Last Man and there's a much more traditional Vampire theme to them(garlic, mirrors, stakes, etc), the Plague is Natural and not Man/Woman

P) Made, there are no uninfected survivors just those who are taking the medicine to keep the infection at bay, the main character in Last Man spends his days hunting the Infected and doesn't research the cure until the woman shows up, the main character in Last Man only considers getting a Sports Car then settles on a station wagon for its' practicality, Last Man character is killed by the Drug taking Infected and not the full blown Infected, they kill him because they fear him.
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Despite the complete lack of special effects, Last Man does a very good job IMO of creating a realistic environment for the scenario. Well worth seeing if you like this type of story.