Wait, this poll has nothing to do with Taylor Swift?
I never used it frequently, though, except at work several years ago, since I was on Win2k already, by the time it was released, at home.
But the way Windows 7 renders the graphics, the borders, the animations, and especially the way fonts are displayed, cause me eye strain, and the larger the monitor the worse it is.
My Computer->Properties->Advanced->Performance settings. Disable everything but shadows (adjust for best performance, then re-enable shadows, because the shadows really are good things).
Also, if you want to adjust text, type in "cleartype" at the start menu, and go from there. Text looks exactly the same in 7 as it did in XP (still inferior to Freetype or Infinality, IMO, but tolerable with good font choices). It is being rendered by the same engine, the same way. Any differences will be due to custom DPI scaling settings (likely not set) and default anti-aliasing settings.
IMO, it's a good idea to get Consolas and Deja Vu, and set your monospace fonts to either Consolas, Lucida Console, or Deja Vu Sans Mono, then set most UI fonts to either Deja Vu Sans or Tahoma. Then, once that's set up, play with the Cleartype setitngs a bit, until they start looking more, "right."
<- almost as finicky about font rendering as a Mac person...almost.