What memory config are you looking to run? If you want to mess with 4xDIMM configs you actually want "worse" topology, e.g. T-topology. If you're trying for 2xDIMM then of course you want daisy chain. Keep in mind that it is your IMC that is more likely to limit your max memory overclock (assuming you want 1:1), rather than the motherboard, and there may be some performance benefits from running 4xDIMM instead of 2xDIMM.