Well let's start at the top.
She's just flat out unqualified and it's an obvious pander and an insult to the office of the VP. McCain and his handlers trying to claim she's qualified is weak, if she is, then so are all of us. This is the key here, if you feel your mom could run the country then ok vote for her and McCain.
She has a state school degree in journalism, would never have been elected to anything outside of the PTA if she didn't reside in Alaska.
She's being framed as a reformer and on day 1 proclaimed from on high that she was totally against the Bridge to Nowhere, when in fact, she was all for it, and many, many other pork projects when that issue was still under the radar.
She is an obvious wingnut who believes even in the case of rape and incest that abortion shouldn't be legal. How anyone can sentence a woman to that fate is beyond the pale.
She is an extreme partisan who has used her office to retaliate against people due to personal issues, this is more of the same, sounds like the W Justice Department to me.
My number #1 reason however, is that she claims to speak for God and his will. This should automatically disqualify anyone from any office in this country.