I had problems with the F5E BIOS, after the first install the system booted up fine and stress testing went fine, I soon noticed that I could not resume from S3 Suspend (standby), system would just re-boot. I re-applied the F5E bios and set "retain DMI settings" to disable, and also loaded the default CMOS settings from within Q-Flash, and applied "Fail-Safe Defaults" before applying my BIOS settings. S3 suspend worked ok but I noticed a problem with my Soundblaster Audigy 2 platinum pro did not have access to all of it's inputs, missing Line-IN 3 and SPDIF-IN which I use regularly, The only way that I could find to get my inputs back was to go back to earlier BIOS, I then loaded F5E again, I did have all my inputs for a while but I lost them again, I think turning off the power supply switch may have had an affect but I am not sure, I have not had the time to try to confirm. going back to F5B BIOS resolved the issue again. I will stay with F5B for now.
Maybe it's just my board but it seems to have a flaky BIOS, I had trouble in the past, a few days after upgrading to F5B I spent a couple of hours troubleshooting a problem where I could not get the system to boot at all, would just hang trying to boot from a CD or from the HD, even pulling the battery for several minutes did not fix the boot problem. Turning off the setting for USB mouse support allowed the system to boot, I checked several times, it would not boot with USB mouse enabled but would boot with USB mouse disabled. The Next day I was able to enable USB mouse support again and I have not had that issue since.
System: GA-N680SLI-DQ6 Rev1, E6600 3.2Ghz (357x9) 1.45V, Zalman 9700, (4x1GB) Crucial Ballistix 2.25V 5,4,4,12 1071Mhz Unlinked, Radeon X1950, Soundblaster Audigy 2 Platinum Pro, 3 x 500GB Seagate SATA 2 HD's (no RAID), Sony SATA DVD Burner, Antec P180 Case with Antec Neo HE 550w PS
Kevin