I live in North Ridgeville, OH (about 10 miles west of the Cleveland line). It is by no means Ghetto here but if I had to pick the worst spot, it would be the trailer park up the street. My Dad lived in that park when he was 4 and it was GHETTO back then! There are trailers in that park that are over 60 years old!
As far as Cleveland goes, ANYTHING between downtown and East 200th over to Broadway is just plain GHETTO. I worked that area for 2 years and there is not a bright spot anywhere. Cleveland as a whole is just sad. I believe it is on the list of poorest areas in the country. Detroit is about the same (maybe a little worse). The thing is that the outlying suburbs are booming but it will only be a matter of time before the urban crawl catches up. Many people who live in the burbs work in the city so if the city is dying, the burbs aren't far behind.
Now, from what I hear, Columbus is booming (a lot of headquarters for large companies which is always a good thing). Not long ago, Columbus was in real bad shape. I guess it helps to be the capital. Wouldn't want the politicians working in a ghetto would we?!?