Given you got to level 22 you probably arent totally clueless.
Best tip I ever got for any Vector TD games: Blue.
Blue is your key. You need to keep slowing down the invaders EVERY step of the way. Also, level 1 blue's slow down just as well as level 10. Dont bother upgrading to level 10, its a waste of money. Just use lots of them at level 1. Also, forget greens and purples. They are OK but eventually underpowered for the money. And dont make any more Red lasers than absolutely required, dont upgrade them too much. Go for a red rocket ASAP and upgrade it to get extra range, enough range to cross over and hit another path.
ALWAYS go for the interest bonus points. The other bonuses are a waste. All you need is lots of money. Everything works out with lots of money.
Again, red spammer and red rockets are the best value for the money. Use them in a ratio of about 10:1 with the blues. Remember, blues slow down things enough that reds can hammer them 10 times as much as they would without slowdown.
Lemme find you a demo map of a really good setup.
http://blogs.warwick.ac.uk/images/johnwaller/2007/07/13/vector_td_screenshot.jpg
Actually this guy is a little short on the blues. Ideally you wanna start hammering the invaders as soon as they enter the screen ( and start slowing them right away too) and keep hammering them until the very end. I also wouldnt waste time with the green towers. Even at level 10, a type 3 green just isnt that hot. Better to nail green invaders with super powered red towers the entire time they are moving.
With these strategies, most maps are relatively easy all the way up to level 50. Notice how the dude has assloads of cash at the end? He was smart and only spent as much money as he had to, even if it meant letting a bad guy slip through once in a while. The interest piled up.