Here is the thing that you appear to be missing. He was using lefties as an example; it could have been blue eyed redheads or whatever. I think the point he was trying to make was that pandering to a tiny proportion of the population and hence your customer base, while simultaneously alienating the majority of your customer base doesn't make good business sense. Which is sorely lacking these days in companies that are more concerned about being "woke" and promoting a lifestyle that the vast majority of the population doesn't agree with. Even if it costs them money. I wish some stockholders would sue said companies for costing them money, but I doubt that'll happen.
Its one thing for people to be willing to tolerate and ignore the small fraction of the population that they disagree with (I fall into that category), but said tiny fraction isn't willing to be tolerated and ignored. Noooo... they get all zealous and work hard to shove their agenda in people's face all the time, dying to get the approval of the majority of the population. They want those "atta-boys" and "Yea, you rock". Again, it doesn't really matter what the agenda is for purposes of this conversation, it could be anything that flies counter to cultural norms. It's the religious levels of zealotry in shoving it in everyone face, be it in popular culture, movies, video games, even the schools, that tick people off and generate dislike for said tiny minority. Its pure propaganda, pure and simple.
I can tell you, I don't get up in the morning and think about X, Y, or Z group that I disagree with that day. I have far more important things to worry about. But when I get bombarded with their agenda in every form of media and all of a sudden we're "phobes" if we disagree (but not do or say anything bad or disrespectful to said tiny minority), it gets my hackles up. So I go out of my way to avoid buying products from companies that get all pushy like that. Good to know that the publishers of Mass Effect need not worry about receiving any money from my wallet.
Incidentally, the tactic of calling someone a "phobe" right off the bat is a pretty lame one; its the equivalent of calling someone a racist in an attempt to shut down the conversation because you have no other effective argments to make. Its effectively the zealot's nuclear bomb of insults, but frankly, it has lost its effect with many people due to overuse and misuse.