There are going to be a lot of workout fiends pissed to hear this.
Personally I don't know what to make of it since the FDA has no credibility imo, but that's not to say they are always wrong either.
Arguably, they are doing their job in this case, imho.
1,3 DMAA [aka Methylhexanamine] is a fairly potent stimulant, acting as a vasoconstrictor and norepinephrine releasing agent.
I don't necessarily agree with bans, but these substances are hard to control. People can kill themselves by taking too many caffeine pills and conducting some athletic training, but aside from pills, it tends to be self limiting and dangerous doses tend to induce negative effects regardless.
Many people can take high doses of DMAA or ephedrine and not really put themselves at risk, but other people may have sensitive hearts or whatever. These substances, in excess, and when the body is pushed to the limit, appear to bring out even the smallest flaws in our faithful heart. And hell, who knows, maybe these people might have died during physical activity at some point, even without stims.
BTW, you can still buy ephedrine, just in the natural form of ephedra-containing products. Bronkaid and similar products marketed as bronchodilators are still available on store shelves, and contain the active ingredient ephedrine in precipitated salt form.
I'm still not really sure how I feel about the FDA banning supplements that contain various lesser-understood stims, based on people dying with them in their system... but this is what the FDA is supposed to do: regulate available products and remove any that seem to even have the potential to cause adverse reactions. Overreaching? Perhaps.
As much as I am a fan of letting the Darwinian approach do its thing, and quell the population in any way shape or form, I think it's also an intelligent approach to keep these things away.
Also, there are plenty of pre-workout supplements that don't now, and have never contained DMAA, and still retain raving fans of said supplements.
After reading various anecdotes of Jack3D and other 1,3 DMAA-containing PWOs, I've actually been avoiding supplements that contain it. I'll have to reread the label of the C4 Extreme I just bought to see if it's listed under Methylhexanamine instead of DMAA (which is all I looked for originally). I already have issues with inappropriate caffeine and ephedrine intake, and don't really want to push it with even more stims.
Some people rave about these products, some don't experience any negative effects, but some people have a hardcore crash after taking any PWO with DMAA.
I might have to grab a tub of Jack3D just to have in stock after it's removed from shelves. I'll rotate dosing on my workout days with other products, to try and minimize any tolerance to DMAA. Hell, that might even help my workouts, since I have built up quite the tolerance to other stims (trying to cut back, failing miserably).