It's about what I make now, so I wouldn't. I imagine it depends on your prospects for making more money where you currently are, the difference in cost of living between here and there, and finally social factors such as family.
If you're making $70K where you are, but there's a possibility of making $80K if a position opens up in your current town, but the cost of living difference eats $15K of your new income, you're talking about leaving your friends and family for $5K. What seemed like a $30K increase wasn't.