I tried it yesteday. Game feels even more awesome than before

I went with a bit different build than I thought initially. Went with str5 (4+book) for heavy gunner, per5 for demolition, end4 for chem res, char3 for lone wanderer, int9 for nuclear, agi1 (won't be using VATS), lck2 for scrounger. Took nuclear asap, got 4 fusion cores from Abarnathy Farm (high chance to spawn) and I'm set with armor pretty much for the entire game.
Everything weighting something is awesome. Drugs/stimpacks giving thirst finally makes all the water useful. Getting hungry, ill, etc makes the game so much more enjoyable. The rad-removal workshop item is next on my list, don't really want to rad-away my rads (severe and long penalties for using rad-away). Also the need to walk everywhere makes the world feel so much bigger and more dangerous. Gives you also an effective range, especially since no saving means you gotta look for beds or plan ahead for a round trip

Need also food / water or eat what you find when you run out of

Love it!