After playing for maybe 6 hours here's my quick list of positives and negatives
+ Nice setting, world feels lived in
+ Enjoyed the intro, thought it was quick but interesting and a lot better than New Vegas
+ Crafting seems excellent, very detailed and a step up from Skyrim
+ Guns have a nice feel to them and VATS is still useful
+ Audio is excellent.
+ Not many bugs or glitches so far
+ Seems to be a strong selection of weapons (not sure about armor yet)
+ Good performance, as to be expected.
- UI is terrible, just as bad as Skyrims.
- Don't like the new perk/skill system mash up. Not sure why they felt the need to fix something that wasn't even broken. This is a big deal.
- Graphics are mediocre and it feels like a reskinned Skyrim
- Some of the voice acting is surprisingly bad
- Map feels a bit compressed, there's hardly any open areas.
- You cannot see holstered weapons on your character. Wtf