It actually wasn't that bad, but I used a rather large loophole to do it.
Since the bee nerf, there are not many ways to solo him that I am aware of. But one thing they haven't done is taken care of the rocket launcher glitch with the gunzerker.
The way it works is, while gunzerking you put any high damage item in the right hand, and an explosive in the left. The explosive damage from the left hand item will pick up the base damage of the right handed weapon. So I used a 12 pounder RL in the right with 430k damage, and a purple torgue shotty with x16 pellets (and god awful accuracy) in the left. Combined with an explosive relic I was doing about 7 million a shot with that shotgun. But that was on Marcus's target dummy. Hyperious was taking somewhat less, but still probably around 4-5 million each time. Also don't need the bee sheild, just used a blue adaptive for some more health. Skill set up is whatever you want, but I found it works best to focus on the rampage tree so you can gunzerker as quickly as possible.
Tried other set ups but this works the best. Somewhat above just hitting him with babymakers, but not much. You still have to work on the adds, since when he is sheilded it won't hurt him. I don't mind using it, b/c I think the way they have him set up is bs, but that's my opinion. Still somewhat of a risky fight, and it takes 5-10 minutes once you get the hang of it.
Also the items are not terribly hard to find so anyone with a zerker could do it which is a big plus. Only warning is that using this makes the rest of the game a total cake walk (basically one-shotting every single other enemy in the game), so I would recommend only using it for boss encounters to speed the process.
Off to try out this new DLC.
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I think every time it happened was when I was using two weapons of the same type, but that might just be circumstantial as I almost always use two weapons of the same type.
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