Settings vary by camera; the more upscale the camera, the easier it is to change settings as there will likely be a dedicated or programmable button for the setting. The lower-end and compact cameras force you to dive into menus more often, and sometimes the menus aren't laid out so well. But this is not a brand-specific thing, as all companies do this... it's deliberate because they want to upsell you to the more expensive model with more dials and buttons and stuff, and make more money in the process.
The newer Nikons actually have built-in help into the camera software itself, as do other brands like Sony. I think Canon does the same. The companies all copy each other so whenever one company innovates a bunch jump on board. I've used Canon, Nikon, Sony, Panasonic, and Olympus mirrorless, compact, and DSLR cameras, and the differences in learn-ability aren't that big.
For Auto mode I think any of the cameras I've used have been equally easy. It's freaking Auto. Not sure what "beginner" means, but for Aperture-Priority mode (which I use 99% of the time), I would say that the Pany M43 interface is easy as pie, as is the Oly M43 interface, followed by the marginally more difficult Sony Cybershot RX100 interface (NOT the Sony NEX; I haven't used those but I've heard bad things about how NEX is laid out, though I've also heard that the newer NEXes aren't as bad), followed by CaNikon.
If your friend is that kind of person s/he'd probably pore over the manual anyway, so why would s/he care about how allegedly difficult it would be to learn?
Last note: Canon makes some very good stuff, especially at the pro level where the bodies and lenses cost as much as cars. However, Canon's lowest lines aren't built as well. Hold a Canon Rebel and then hold a Nikon; most people will agree that the Nikon feels better. Then compare lenses.. both companies make good glass, but the cheapest Canon lenses often don't even come with lens hoods! Furthermore, Canon lenses come with 1 year warranties; Nikon lenses come with 5 year warranties. That kind of speaks for itself.