I fixed my uncle/aunt's computer last year. Between Spybot and Ad-aware, they had nearly 1,000 hits. I also had to run both programs like four times, and each time new things with higher threat ratings were uncovered.
I also found out where all these problems came from. My 14 year old cousin told me, "You know I found this thing on the 'net, and I didn't know what it was, so I installed it! Is that cool or what?!" No... not cool. I nearly choked. I told him to never do that again, but I suspect I'll be reinstalling Windows on that computer again soon. Good thing my uncle has a real nice administrative job for the New York state government, so he can afford his son's TDTO habits.
MoonSword