Always cracks me up when I see this. As though that's somehow going to sway me against purchasing an otherwise ideal car. Honestly, it has never even been a consideration for me.
Also, why mention the IS250 but not the IS350? Personally, I think the IS250 is underpowered. Get the IS350, it is worth it.
I agree the IS250 is a bit weak and unsatisfying personally, but the OP specifically mentioned that he didn't care about speed/performance, so the average ~$7k saved might be good for him. If I was gonna have an IS, it'd have to be the 350. The IS-F is cool, but at that lofty price point I'd have a near-impossible time choosing it.
As per timing belts, the OP said he hoped that he would die before the car, hence someone who wants to drive the damn wheels off the thing and keep it until he can't drive anymore. Not the most realistic idea, but some people do it

Not having a timing belt on a regular reliable motor like the VQ is a bonus, particularly for people who drive ~25k+ miles per year. Timing belt service is time consuming and $$$, unless you do it yourself, then it's still a small PITA. AFAIK, I haven't heard of any VQ's under 200k miles that needed any kind of timing chain service, and I've seen a lot of the VQ30s with almost 300k miles with no rebuild, gaskets, etc ever done to them. So it's kind of a nice thing. I'd imagine that on some higher-strung motors that the timing chain might need service nearly as often or as often as a timing belt, but the VQ doesn't seem to be like that at all.
as far as nissan, timing chains are pretty reliable on the 3.5/3.7 engines. replacement is probably 6-7 hours or so (flat rate labor), so costly but not horrifying given the parts are not that bad. but if you're tearing the front covers off it's probably because some dick didn't change the oil and the VVT stuff is fubar (and cam sprockets and covers (house the solenoids) are not cheap at all). with proper oil change intervals, that's a pretty decent motor. i would just say its dings come from not being QUITE so reliable as the honda engines plus their transaxles.
also, to whoever said brakes/tires are more expensive- try about 4x as expensive. the stuff costs a lot more in the first place, plus you're changing stuff out twice as often. then if you get to people who warp rotors (98% of them) and those that don't have their tires rotated, their is a SHITLOT of routine upkeep (some caused by owner error) on a majority of luxury cars.
Definitely
