I've moved back to Chrome for a while and there are still some things that nag me.
The Ctrl+B, Ctrl+U shortcuts don't work to bold / underline highlighted text when composing a post.
When you point at a topic and the pop-up mini preview appears, it seems to appear at random locations frequently...and I'm left waiting for it to appear near my mouse.
...other annoyances:
When I copy a URL from the address bar, it's not copied as plain-text (!?)...so it effs up the formatting of some things you paste the URL into.
In other browsers, I frequently right-click a tab and press "C" to close when I'm using a mouse with an iffy middle button. My left hand is always on the keyboard and this is much faster than zeroing-in on the tiny little "x". With Chrome, this does not work. FYI, this works for title bars, taskbar buttons, and tabs in almost every application.
The icon doesn't have a large version, so it looks terrible on my Media Center PC with XL desktop icons.
It's annoying that I can rarely ever see a page title without pointing to the tab for pop-up text.
Some of your problems don't seem to be centered around an actual Chrome problem.
I can see how the URL bit might be an issue, but it doesn't take more than a paste/copy into something else to get plain text (like WinKey+R, paste, Control+A, Control+C, Esc). How often do you copy/paste URLs into a program where it would matter? Are you keeping a list of bookmarks in Microsoft Word or something?
To close a tab, press Control+W. Left hand, no mouse involved, much faster.
The resolution and screen size you choose are not Chrome's decision, so don't blame Chrome that you can't read text size or image size
All of my alt text comes up right next to my mouse in chrome, every time. Neener neener!!
Control+U is the shortcut to show source. I'm not sure if you can change that or not. However, if you're used to moving your mouse to right-click and close tabs, it shouldn't be too hard to control-select the text you want to edit and using your mouse to click the B/I/U buttons. Kinda a trade off for Control+W, isn't it, hehe.
Since you apparently use tabs quite a bit, have you found the Pin Tab function yet? It's pretty handy.