Played 7 hours on high settings so far, not a glitch or CTD on my Phenom II 955 and Radeon 4870 1GB running at default with its original driver. Hope I'm not jinxing it.
My character.
Drusilla, a Breton evoker/sorceress, is not a nice person. She is obsessed with achieving immortality by becoming a lich and the foul magics she has tampered with have darkened her soul, blackened her eyes and taken a toll on her skin. Upon escaping Helgen, she immediately returned to loot the corpses of the fallen. If the dragons don't burn a town, she might... :sneaky:
I'm gonna post in the Elder Scrolls forums mod proposal thread and suggest a high-level quest at the end of which she might achieve her goal, with advantages and penalties once she does become a lich.
Drusilla just cleaned her first dungeon: Cracked Tusk Keep. Found something interesting in its vault and went up a level to #5. Conjuring a fire atronach makes things a lot easier than just a puny wolf familiar. Money still scarce but she now has enough to buy herself some robes of conjuring.
Life's good.
Lock picking's tough though but she's learning.