Jon Favreau's directing. Good sign, in my opinion. I think this series may mock sci-fi tropes - and you'd expect that from Seth Macfarlane - but will still have real action/drama worked throughout, a la Galaxy Quest. A straight-up parody won't last long and wouldn't be very good. Galaxy Quest was a parody that wasn't, and only had to last the length of a movie. So a trailer that isn't just stuffed with one-liners is a good thing.
It all comes down to the writing and execution, though. The casting could work for or against it. Comedians like Seth MacFarlane and Norm Macdonald often end up playing themselves, which isn't necessarily a bad thing in a parody movie, but could ruin a sci-fi show.