I think that "never" is difficult to support, as our understanding of physics could change dramatically in millions or billions of years. The cliche quote is that "sufficiently advanced technology is indistinguishable from magic."
With our current understanding of the universe, I think it's unlikely we will ever travel beyond our own solar system, unless it's an "ark" carrying families who live their entire lives onboard and procreate to produce the next generation of passengers. Space is just too big for anything other than FTL, which currently seems impossible.
Talking about hitting something, I don't think it's a huge concern. I've read that the average density of the universe is half an atom per cubic meter. Obviously this varies dramatically based on your locale, but it seems fairly unlikely that we would occupy the same spacetime as something large enough to damage a ship during a journey of a few years.