The righties and the lefties have points in this disucssion, but people are failing to see the details.
When compared to the overall federal budget, the sequester will do near nothing to dent it, and does not touch the biggest entitlement spending from medicare/aid and SS. More cost controls are needed in those areas, and this is where the greatest cost savings can be achieved; not in the agencies with tiny budgets where you see miniscule impact in overall budget, but highest impact on communities and services.
Since most agencies have much smaller budgets than the DoD, medicare/aid, and SS the cuts will disproportionally hurt them more. When compared to an agency's budget and plans which is a mere fraction of some of the other larger agency's budgets, a 10% cut can seriously affect employment and reduce staff. For example, an agency or program with a 100M budget that is already understaffed and under budgeted will face significant delays, staff layoffs, delays in infrastructure (IT or otherwise) improvements and security updates. These also affect the economy in the local areas as well. DoD base cuts and closing down national parks affect local community economies much more than shaving off a large amount of cuts in medicare/aid would. Also, there is no reason that cuts should be spread equally through all agencies. FDA, ICE, and similar essential services should not be subject to the same priority as say Arts and Humanities programs.
Also, many agencies may not be able to complete current programs or projects on time with this cuts. This would require them to either delay or reduce the scope of the work. For many contract setups, this would require re-negotiations and penalties for changing work, which end up to $$ paid to the contractor.