I think it would kickass to win like 300 million jackpot, Take home mayb 100-150 million lump sum.
Retire my wife's parents and my parents, let them do whatever they want, or start their own business, whatever.
Buy big houses for, sister, sister, father, mother, wifes: mother/father, sister, brother
Start up some fun business and employee whoever I want to in my circle of friends and family.
Probably buy a 20-50k car for a lot of people, and send out a bunch of free vouchers for cruises or flights/vacations
If you invest a large portion of the winnings it would be possible to help a lot of friends and family for an extended period of time.