While I'm not exactly fond of spiders, they don't bother me too much. I usually only kill one if its bothering me, like crawling across the floor where I usually walk. If its up in a corner I usually leave it be, unless its particularly nasty looking. Here at my apartment we've had quite a few recently. I'd say between my roomate and myself we've killed probably 20 or so in the last few weeks. We should talk to our landlord about it since there've been so many, but oh well. The only one that really bugged me was the one that was on my bed, but he was probably just hanging watching some tv and surfing porn so I guess I could forgive him.
Back when I was a sophomore in high school my mom and I moved to a new house. There must have been close to 1000 spiders on the outside of the house. Well, my friends and I got a bucket and just knocked them all in it and let them have a huge Royal Rumble. There were a couple of BMF. Gave them a nice dousing of Raid and various chemical cleaners to ensure the death of the survivors.
Makes me think of this one secret stage in Doom 64 where its just basically steps and about 50 Spider Demons.