Really? What distance? What choke?
IC - at 30 yards puts out a pattern of 2 feet. Close quarters is likely a lot closer to a foot.
I would assume most home defense weapons are open choke, and have an even wider pattern.
As for the length comments some have made, buy a home defense weapon and it should be quite short. Pistols likely would put out a bit of recoil, so a lady may not do well. So a foldable stock may be required so the mrs. can shoulder the weapon.
Actually, something like this might be a bit more appropriate for a lady:
http://www.gunsamerica.com/91798247..._RIOT_HOME_DEFENSE_18_1_2_W_FOLDING_STOCK.htm
Problem is you have to be a bit more accurate due to the size of the pellets and the smaller rounds. As someone else mentioned, you'll probably want to avoid semi autos. I love mine, don't get me wrong, but they are more likely to jam than a pump. And the jams are often harder to fix.
Granted, if it was just you using the thing, a pistol gripped home defense 12 gauge pump would be optimal.
And practice and become familiar with the weapon.