I tried watching all of everything several years ago, and I do tend to have one or two types of substances coursing through my veins whenever engaging in such activities.
TOS, I only lasted 2 and a half episodes maybe. I did make a point to watch the Kahn episode, and thought that was pretty good for the time. I had to skip most of the Next Generation because it was generally terrible outside of about 5 or 6 episodes.
I thought Deep Space Nine was overall rather solid, but also very stupid at times. The main head dude was a terrible actor. I think it had the best long-running stories of the bunch, what with the Dominion and the Kardashian family and the shapeshifter dude and his slime people. I was entertained by Voyager, even though much of it was admittedly stupid. Still, it was the most entertaining of those, as I really like the theme of being stranded out in the middle of nowhere and having to figure shit out. Plus, none of that boardroom politics horseshit. I thought Enterprise was pretty awesome, all things considered. I don't generally like "prequels," but for this series I found the idea of the humans/federation learning how to not fuck up the universe by proceeding to fuck up everything they encountered was pretty sweet. I liked the primary bad/good guy and his race that they were working with/fighting throughout the series. Whoever that actor was is the best in all of Star Trek, imo ...but then that time travel hogwash near the end muddled things up.
Oh, and T-Pol: holy shit.
I think if I was living in 1964 and tripping balls most of the time, TOS would be rather groovy. But nearly all of those shows are super dated, even though I can appreciate how revolutionary TOS was at the time, and more socially than simple TV entertainment.