Nah, they'll ride the current wave until it starts to falter. Guardians 3 on the way in a couple of years (which will likely be the biggest yet since it also includes Thor) will keep it going for at least a bit longer (it'll basically replace the Avengers for the big teamup movie). They can fairly easily pair Captain Marvel in that too. Heck, if they want to give it another boost, they can kinda run with what Fox was doing with X-Men, as if I remember right, the Dark Phoenix Saga involves some universal strife.
They have several smaller movies queued up too. They've said they want to do a Black Widow (think the favorite is for it to basically be an origin or at least where it'd build out her past) movie. I'm sure they'd like to find a way to make Hulk work (they kinda did by shoehorning Planet Hulk into the Infinity Saga with Thor Ragnarok). I'd say that if they want to do a new Wolverine maybe do his comic origin (where he faced off against the Hulk), where you've got two strong characters and you wouldn't need a normal origin story for either. There was an animated movie (Hulk Vs, had two parts, one was Hulk vs Wolverine and the other was Hulk vs Thor) that had Deadpool (and some others, but Deadpool being a huge success would be a factor) in it and could make for an easy to translate story that would let you do justice of Hulk and Wolverine with Deadpool for comedic affect (where they could really make the other two more mean and vicious than they've been in any movie and so we'd get a new side of them, with Deadpool cracking wise).
They have a lot of smaller esoteric movies that they could do before any serious reboots. Squirrel Girl for instance.
