Change the constitution, put laws in place that limit the types of guns people can buy, make guns more expensive, more waiting periods and extensive background checks, change the supreme court to one that would roll back Heller, etc... Hell, go abstract and have a state pass a law that says everyone over 18 is now a part of the state militia, and as a regulation on the militia, only the State armory may maintain firearms, and private storage is forbidden, just to play up the the "originality" meaning of the 2A.
The Constitution isn't a stone tablet with immutable meaning. It just has whatever meaning we choose to give it and what some politicians in robes say.