I don't actually own the One, but I played with one for a few hours. I really liked the "feel" of this remote compared to other Logitech remotes, which is laid out much better. I did have a little problem with using the touch screen, but I am used to using a remote with a larger screen with action buttons on each side of the screen. The limit of 6 commands per screen was a problem for me. I think it is a very good choice for a remote costing $250 and is fast becoming one of the few remotes that actually let the end-user have access to programming software.
The IR is pretty narrow and wouldn't pass commands unless I pointed the remote directly at the device being used. To be fair, my HD-DVD player IS partially blocked by my HUGE center channel speaker. LOL
I am going to get hands-on with the Universal Remote MX-980 first before getting the Harmony One. The Remote Technology stuff is out-of-the-question now since I don't want to bother an installer when I want to change an icon, move around devices, or program in a new device. The MX-980 is also a dealer-only remote but my dealer is willing to give me the software and the 300MB update since I am 100 miles away.