If they're very far advanced:
1) They won't see us as a threat or worth dealing with, and ignore us and be on their way.
2a) See us as being as trivial as bacteria and steamroll past any defenses we can put up.
2b) They might be so advanced that we wouldn't even see them as a life form, and so would not put up a defense because we didn't know how, or wouldn't have time. (Like a gravitational weapon that abruptly increases the effective attractive force of the planet's core by a factor of 50. Good luck against that.)
Clearly someone hasn't seen the documentary on this. I think its called Independence Day
Humans > *