sorry if i'm not understanding, but can you explain how it doesn't work by rendering at 2048*1536, then downscale the final image to fit the physical resolution of, let's say, 1600*1200, which is still a 4:3 aspect ratio?
the text below from anand's macbook retina display review
If you select the 1680 x 1050 or 1920 x 1200 scaling modes, Apple actually renders the desktop at 2x the selected resolution (3360 x 2100 or 3840 x 2400, respectively), scales up the text and UI elements accordingly so they arent super tiny (backing scale factor = 2.0), and downscales the final image to fit on the 2880 x 1800 panel. The end result is you get a 3360 x 2100 desktop, with text and UI elements the size they would be on a 1680 x 1050 desktop, all without sacrificing much sharpness/crispness thanks to the massive supersampling. The resulting image isnt as perfect as it would be at the default setting because you have to perform a floating point filter down to 2880 x 1800, but its still incredibly good.