In Tom Clancy's Sum of All Fears he goes over in highly precise terms what it takes to detonate a nuclear bomb. In The Bear and the Dragon they modify the Patriot missle system (mentioned above) to be able to intercept a ballistic inbound.
To Sum up Sum of All Fears (pun intended), a ball of uranium is wrapped in a set of shaped charges (charges that shaped to explode with the bulk of their force going one certain direction) that will compress the ball of uranium to something the size of a pencil erasor, etc. the wire lengths that run from teh detonator to the charges themselves must be the exact same length, lest one charge be early or late and screw up the entire process. As we all know from rudementary physics (you WERE paying atteniton in Jr. High weren't you?) when you compress anything it heats up, well when you compress uranium that much it is heated up enough so that things begin to merge and mutate, and that's where the story gets hazy for me. There's soemthing about tritium (hydrogen-3) being injected into it that makes the reaction really go, and the matter that is lost in all of the merging of atoms is converted to the enery that equals death and destruction. I could dig out my copy of the book and give a more detailed explaination, but if you wanna know go to the library and pick up a copy, damned good book anyway. The point is, unless it's really crummy explosive used to compress the ball, you could shoot one out of the sky with whatever works, and so long as no electrical charge is applied ot the charges to detonate them, the nuclear reaction isn't going to happen. Like with C4 explosive, you can stomp on it, set it on fire, freeze it, throw it, etc. and it's just inert. Apply an electrical charge and boom. that's one reason it and primacord is so popular in any military action, because it's really hard to screw up with it if you know the slightest thing about explosives.
IIRC, not to give anything away iether, in The Bear and the Dragon they shoot down some nuc-tipped rockets with mini-gun fire from Apaches and Blackhawks, as well as missles, and they produced similar results.
You guys can call Clancy's stuff fiction, the stories are. but his technical descriptions, explainations, and sometimes his predictions are spot on (for predictions read Debt of Honor. WHen you get to the last chapter you will understand.)