"Homebrew" Psilocybin Created By Scientists Using "Widely Available" Materials

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Muse

Lifer
Jul 11, 2001
40,875
10,222
136
I'm ready to microdose. I think you can try it quite safely.

I tripped a lot in my youth, but mostly LSD. Did shrooms maybe like 5-6 times, saw the Pink Floyd laser light show at the Hayden planetarium when that was a thing 25 years ago on shrooms. But I preferred good acid to shrooms. Shrooms made my body hurt a bit. Of course dirty acid could to, but good acid was better to me than shrooms. Tripped many a time at clubs, raves, just walking around NYC or on a hike in the woods. Best LSD I did was black pyramid geltabs someone got from Oregon. Clean as a whistle.

Haven't tripped in over 20 years though.

I don't think I could trip right now at this stage in life, maybe only on the absolute cleanest LSD possible, with a couple great people out in the woods somewhere.

From everything I've read and people I spoke to, microdosing psilocybin has zero tripping potential. It can just help you rewire your brain at that time. In a negative feedback loop in you head to start the day? Try a capsule and you can turn it around. Read an article about a study that showed psilocybin can create new neuron pathways https://news.yale.edu/2021/07/05/psychedelic-spurs-growth-neural-connections-lost-depression

This is particularly interesting to me as I suffer from bipolar depression.
I was never fortunate enough to know people who turned me on to sources for psychedelics. Well, I did know people I could have asked, and scored (they did them) at one point but I wasn't in a space where it made sense to me to pursue it. Nowadays, I know a person or two who I could ask, but haven't seen them since the pandemic shut down my volunteer gig. One of them did lay some nice grass they grew on me before the pandemic, so I have that.

I'm up and down but don't know that it's bipolar, I think it's just natural stuff. "It's and up and down world."

In terms of microdosing, I have to look that up! It's a new concept for me. I suppose it would be wise for me to do something like that, take a little, a lot less than a _standard_ dose (which when Leary and Alpert were experimenting, was 400 micro grams for LSD), at least at first and "see how it goes." Get my feet wet, get some confidence, comfort. A full dose, even people who have experience can't be sure what might happen. These are NOT recreational drugs.
 
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Bitek

Lifer
Aug 2, 2001
10,676
5,239
136
I paid attention to the psychedelic scene. Psilocybin, LSD and mescaline (the psychoactive compound in peyote cactus), is what I heard about in that journal. There are newer drugs, and I'm pretty unaware of what they're about, MDMA (ecstasy), and others. The difference that I'm aware of in the 3 psychedelics I have read a fair amount about is how long the trip lasts. IIRC, LSD around 8 hours, psilocybin, somewhat less, IIRC. It's good to know what to expect in some degree! Of course, part of the adventure is not knowing what to expect and that's key with psychedelics, at least if you're among the uninitiated. I suppose if you've taken them a lot, you have a better idea. But I'm not at all sure that you should take them a lot! That might not be a good idea. My impression has always been that you should take them judiciously and anything but regularly, probably never with frequency. Of course, being as inexperienced as I am, take that with a few grains of salt and a heavy dose of YMMV!

I only ever tried shrooms and acid a few times in college.

First two times was shrooms. Only a couple caps and stems. Trippy, but not mind blowing.

Then did acid once. Was different, less mental, more visual than the shrooms. Recall watching my ceiling drywall ooze, puddle, then drip. o_O

Last time was the shroom mega dose. That was the mind f that I described earlier. The actual trip was a mess, but the after effect was awesome. Was done after that.
 

fskimospy

Elite Member
Mar 10, 2006
87,964
55,355
136
Mushrooms have always been by far my favorite drug. One of my very fond memories is from about 15 years ago sitting on a Ko Pha Ngan beach with my (now) wife, high on mushrooms, watching lightning a couple miles offshore.
 
Jul 9, 2009
10,758
2,086
136
I'm not a fan of booze either.
I've had far to many friends and family ruin or end their lives with drugs/alcohol.
In my life i've seen alcohol kill far more people and ruin more lives that all other drugs combined. That is not to say that drugs are good things, they're not.
 

Greenman

Lifer
Oct 15, 1999
22,254
6,442
136
Are shrooms addictive?
Not to my knowledge, I never had an issue with them. I also never had an addiction issue with acid, coke, or meth. I only snorted heroine a couple of times and didn't care for it. I still drink occasionally, but a bottle of good 12 year old whisky will generally last me a year or more.

My entire point is that none of that crap helps. It can be fun, it can be relaxing, it can be harmless to people with self control. But how many different methods of getting high do we need? It's not just about addiction. I know several people that never learned how to be an adult. When faced with any issue they simply get high and ignore the problem.
All that said, I'm not a fan of finding new cheap easy fast ways of getting high. We have enough right now.
 

hal2kilo

Lifer
Feb 24, 2009
26,066
12,283
136
I mega dosed once.

Had the munchies and kept eating the bag like they were fries. May have eaten a whole eighth, IDK, buddy had a whole oz when we started, could have been more.

Hell of night.

Actually, don't know I did much that night. Was laid the f out.

The next morning tho... That was the good part. Woke up into a spirit walk. Transcendent.

Won't forget, and can't describe.

Won't repeat either.
Rainbows shortly after sunrise in Florida. They were really there. Wonderful night.
 

MrSquished

Lifer
Jan 14, 2013
26,067
24,396
136
Mushrooms have always been by far my favorite drug. One of my very fond memories is from about 15 years ago sitting on a Ko Pha Ngan beach with my (now) wife, high on mushrooms, watching lightning a couple miles offshore.
That sounds pretty damn sublime. A perfect setting with apparently the perfect person to have a nice mellow trip with.

One of my best trips was when they had a rave at the liberty state science center and I had super clean LSD gel tabs from Oregon.

I was on the balcony with a great DJ spinning in the room inside, hanging with some good friends, watching the skyline of downtown Manhattan dance for me, including the twin towers.

The liberty state science center had no idea what they got themselves into
 

Pohemi

Lifer
Oct 2, 2004
10,882
16,963
146
My entire point is that none of that crap helps.
Your entire point is invalid because it's based on your biased opinion (and likely the notion of it being nothing more than a "hippy drug"), not recent studies that show that psychedelics could be revolutionary for treating mental health issues like depression and PTSD.

I'm not promoting giving it to everyone, but to say it won't help anyone is pretty close-minded and ignoring what the studies are already showing.

If you're talking about stoners just smoking pot all the time and being lazy...sure, I've known people who've turned out like that as well. But this is specifically about psilocybin as medicine, and I believe it has valid points.
 
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Greenman

Lifer
Oct 15, 1999
22,254
6,442
136
Your entire point is invalid because it's based on your biased opinion (and likely the notion of it being nothing more than a "hippy drug"), not recent studies that show that psychedelics could be revolutionary for treating mental health issues like depression and PTSD.

I'm not promoting giving it to everyone, but to say it won't help anyone is pretty close-minded and ignoring what the studies are already showing.

If you're talking about stoners just smoking pot all the time and being lazy...sure, I've known people who've turned out like that as well. But this is specifically about psilocybin as medicine, and I believe it has valid points.
I never said it wouldn't help anyone.
My entire point is that we don't need to promote an easier way of obtaining it, or that it's a good way to self medicate.
 
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WelshBloke

Lifer
Jan 12, 2005
33,110
11,287
136
I'm not saying that, we can easily see the results of bans such as against alcohol, marijuana, some drugs and guns. They don't work, they never have and they never will.
Bans do work. Not absolutely, but they work.
Hand guns are banned in the UK (mostly), they are legally available in the US. What's the levels of ownership and hand gun associated come in both countries?
Alcohol is banned in some middle Eastern countries. What's the levels of drinking and alcohol related crime between them and the UK?
If heroin wasn't banned do you think we'd have a lot more problems than if you could buy it in Walmart?
 

Moonbeam

Elite Member
Nov 24, 1999
74,744
6,761
126
As with most things with opposite characteristics, there is an underlying understanding of them that can appears at a higher level of understanding. This is my opinion of the understanding of what that underlying identity is. Psychedelic drugs are dangerous because they can induce a bad trip and a paranoid irrational, even dangerous response from a person so effected. To escape the experience, to keep it clamped down, repressed in the unconscious, a person can experience the feeling that one is dying and do anything to try to escape, including having a total psychic break. This happens because the drug can smash through the barriers we have in our minds that protect our ego from bad things we were made to feel in the past, driving them toward conscious memory which we would do anything to keep from happening.

Ignorance of what is really happening, not that we are dying but merely remembering a time when we died psychically, and thus fighting with all our might to stay alive, rather than seizing that as an opportunity to let go with the realization that we are only feeling things we did not know we already and always feel repressed on a daily basis for so so many years, mistaking reality for what is real in our feelings but a lie in fact.

So taking a psychedelic can be like instant psychotherapy, where you blast right through psychic death and are reborn in heaven or get stuck and not making it all the way through, trapped in a state of associations of endless negative thoughts.

So the danger of psychedelic drugs are basic self ignorance, not knowing beforehand the real nature of a bad trip, that nothing negative will happen to you if you allow or manage somehow to die, to let go, to descend into ones inner hell. All of this is well described by the hero's journey, the slaying of dragons with a sword of will and a mirror shield into which one can see the hydra without turning to stone.

The good side of psychedelic drugs is that they can open one to states of consciousness we did not know exist, the collapse of ego and the awareness of Oneness. An ego that has ceased to exist doesn't really need to fear death as there isn't anywhere in unity for separateness to exist.

Of course when the drugs wear off the ego self returns. I suspect there may be other paths where that does not necessarily happen. I know, for example, there are things like Zen Masters and Avatars, Prophets, etc. Not so sure they are here in this world in the ordinary way we experience it.

TLDR: Drugs are dangerous because they can bring into conscious what we really feel. Drugs can be of tremendous benefit because they can bring into conscious what we really feel. What we feel is our inner truth and it is also a lie. Taking what we feel as the truth is the danger. Seeing it for a lie by allowing it to be felt to the root can transform ones inner state in a profoundly positive way. This can also happen without the use of drugs.
 
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ch33zw1z

Lifer
Nov 4, 2004
39,751
20,326
146
Bans do work. Not absolutely, but they work.
Hand guns are banned in the UK (mostly), they are legally available in the US. What's the levels of ownership and hand gun associated come in both countries?
Alcohol is banned in some middle Eastern countries. What's the levels of drinking and alcohol related crime between them and the UK?
If heroin wasn't banned do you think we'd have a lot more problems than if you could buy it in Walmart?

All one has to do is review the last round of ethanol prohibition to see that banning it actually didn't reduce usage.

Drug education, mentoring, responsible use, etc....is the real way to reduce it while alleviating the judicial burden on both LEO's and courts.

If heroin or opiates we're legalized, it possible that usage would increase, but I submit that would be mostly current users.

What you would then see if drugs dealers turning to other things to make that quick buck, which would increase others types of crime, not necessarily opiate use. Plus, opiate overdoses would start to come down because users would get guaranteed purities each time. Opiates have a small margin of error, so variations in purities really does contribute to those deaths.
 
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Jul 9, 2009
10,758
2,086
136
Bans do work. Not absolutely, but they work.
Hand guns are banned in the UK (mostly), they are legally available in the US. What's the levels of ownership and hand gun associated come in both countries?
Alcohol is banned in some middle Eastern countries. What's the levels of drinking and alcohol related crime between them and the UK?
If heroin wasn't banned do you think we'd have a lot more problems than if you could buy it in Walmart?
I was talking the United States, other countries are not my concern or interest.
 

WelshBloke

Lifer
Jan 12, 2005
33,110
11,287
136
If heroin or opiates we're legalized, it possible that usage would increase, but I submit that would be mostly current users.
I absolutely disagree. The addictive nature of opiates plus the euphoria they generate combined with the advertising might of Coca Cola or Philip Morris and them being totally legalised?
No way would usage stay flat.
 

MrSquished

Lifer
Jan 14, 2013
26,067
24,396
136
It may not be your concern or interest but that's just you ignoring stuff you don't like.
Reactionary regressive conservatives think they can learn nothing from other countries. It's part of their absolute lack of the right kind of critical thinking skills that could help make things better in America.