Have You Gotten Your Covid Vaccine? Thread.

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ondma

Diamond Member
Mar 18, 2018
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Actual infections are over 100M, ie 30% of the population.

Vaccination rate over adults is over 50%.

As we've even seen here, antivaxxers, antimaskers and getting covid tend to go together, so the actual immunity rate is higher than 50%.

70% is estimated, it's not firmly known.

When in doubt, look at the data, especially from places like AL, MS. Terrible vaccination rates, poor mask adherence, have had low rates for many weeks.

No reason places like the NE and CA, who have had good vax rollouts and low rates, shouldn't also follow suit and allow masks off for unvaccinated.

If they are not following the data and the science, what are we following?
You must have pulled that 100M infections out of your know where. I double checked and CDC numbers of confirmed cases are 32M. And dont forget, some of the people who were infected also have gotten the vaccine, so may be double counted.

And yes, you are right. 70% is an "estimate" for herd immunity. However, that is probably a minimum estimate. I have seen other estimates of 80%. Covid can also be spread among subjects who are too young to qualify for the vaccine.

Bottom line though, why is it such a burden to you to just wear a damn mask? If wearing a mask nationwide can save even 10,000 or 50k or 100k until the virus is better suppressed, is it really that much of a burden to your "rights" for you and your fellow anti-maskers to show that much consideration to the right of others to simply live or avoid a serious hospital stay and possible long term covid effects?

And as for the hillbilly states having the virus under control while ignoring the science, India is calling you.
 

abj13

Golden Member
Jan 27, 2005
1,071
902
136
It's usually considered bad form to continue to attack someone on a point once they've conceded an error. This generally makes people not want to concede errors, and that's already a big enough problem. All of my other statements are entirely consistent with one another and yes, the CDC should have gone with their best guess.

I think you're annoyed that I won't agree with you and you're trying to find some reason other than that I'm right so you're searching for inconsistencies where none exist.

No its pretty clear I hit nail on the head. Your posts reflect how you haven't been objective whatsoever regarding this topic and is the downfall of any assertions you've made. You felt the CDC made some nefarious decision about masking, and have continually changed your assertion to somehow continual modification of what you claimed the CDC actually did.

Anybody looking at the situation from an objective lens would have asked, how and why did the CDC make the decision they did? I looked at the science. At the time, it was felt that only those who were symptomatic spread the virus and the number of asymptomatic spreaders was not a major part of the equation. Apparently you have no concerns of those presumptions as you have not disagreed with them. Then I examined the reality of how the CDC and the WHO approaches these situations with a risk-based approach. There has been 20+ years of this approach. There has never been a policy towards actually endorsing universal masking. And then I looked at the actual data to support who should mask and who doesn't need to and why these organizations made their recommendations. And you've agreed! There's evidence to support masking healthcare workers but not the general public. Then you brought into public policy and I mentioned the critical mask shortage, and the feasibility of changing the recommendation. All of these variables played into the calculus, and makes the CDC's position justifiable. There is no information, data, or even argument you've presented that the CDC shouldn't have continued their risk-based approach, it was only later did we learn that the science was incomplete. But the CDC took their best guess as you want them to.

And that's the position I have stuck to throughout, and now you annoyed with me pointing out the numerous flaws and inconsistencies of your logic. I'm more than happy to keep on pointing out more of your inconsistencies, don't try to project your feelings onto me.

No, they said that AND they said masks were ineffective. They should have just stuck to saying the right thing and not the wrong thing.

Nope. Please don't try to rewrite what you said. You said very clearly: "This comes back to my original point though, which is that prioritizing them for health workers made sense but I think if that’s the goal you just say that’s the goal. In terms of actual cost to an individual and society wearing a mask costs essentially zero."

No where in that "original point" do you acknowledge what they said regarding masks should be for healthcare workers, nor do you write about commentary about effectiveness.

In fact, they did exactly what you wanted. Now you are just trying to rewrite what you said. You mentioned bad faith arguments, correct?

Because their policy was to DISCOURAGE their use, not to not-encourage it. Those are two very different things.

That's quite a strawman. I'm still waiting for a complete argument as to why the CDC should have dropped their practice of risk-based masking. You've made the assertion, all I've seen now is they should have used their best guess! Well they did, they chose risk-based masking. But saying they should guess the other way not on the basis of any legitimate concern is not a persuasive argument to anyone, as that would mean to ignore precedence, to ignore science, and to ignore the realities of the mask stock.

This is a puzzling way to characterize the findings of those studies but again it seems to reinforce the difference between medical science and public policy. Like, if science shows that condoms effectively prevent the spread of STIs but people don't use them right so they aren't being effective the public health policy intervention would be to educate people on proper condom use, not to say they don't work. It should be easy to see how that would apply here.

I agree, it shows that reading scientific papers is not as easy as it seems. Please answer for all of us, what was the authors primary hypothesis in studies 2 and 4 as this describes their "intention to treat" analysis. As in, the authors hypothesized that masks would _________. Please fill in the blank for their primary endpoint. I am being very precise in my language because you have been very loosey-goosey. Did the authors accept or reject their hypothesis for the primary outcome?

And think about the problem of post-hoc testing. What other factors would be associated with someone who was randomized to wear a mask and was willing to wear it vs someone who was supposed to and didn't?

No, this is entirely consistent and entirely correct.
Nope. You now agree there's no clear evidence to support universal masking.

Right! It's okay to take chances and sometimes those chances are wrong. The issue with hydroxychloroquine was that people kept pushing it long after we knew with high confidence that it didn't work. Pretty stark contrast with masks there.
Hydroxychloroquine continued well into early May. But most hospitals moved away from using hydroxychloroquine before the major clinical trials were completed. So that's not how it happened.

But the point, again, is that decisions can have consequences, some with major negative outcomes. As discussed below, you're very much happy to railroad over those possibilities especially when it comes to masking.

We have already discussed this repeatedly, I'm confused as to why you keep asking the same questions. Rationing the masks was fine (and it's what we did!). There was no need to say masks were ineffective when they didn't know that. Then again, I think most people didn't believe them anyway because as I mentioned their messaging was essentially 'these masks are critically needed to protect health care workers but they won't protect you'. I strongly suspect the average person's reaction to that was 'you're full of shit'.

Saying we discussed it when you never discussed it isn't an argument. I'm sorry. There were 30 million masks in the national stockpile, how could have that supply been sufficient for healthcare workers and the general public if they followed what you wanted to recommend? This is a question of feasibility of what you want, and interestingly enough you won't address. How would it have been feasible with that supply?

I have no idea what the CDC did.

Why would you care about the publication date? Instead of actually addressing how the CDC reacted to changing information, you are more concerned about a publication date and not knowing what the CDC did. Well, that's one way to not address what I said.

I'm not sure what the confusion is here - I'm saying that efficacy data was irrelevant as to the appropriate next steps of manufacture and distribution. There was good reason to believe the science would eventually show they would be effective so the right answer was to spend essentially unlimited sums of money on them even before that evidence was available. The risk/reward balance was so asymmetric as to justify basically any amount of money.

So, throwing money wouldn't have addressed the infection count at all but who gives a shit? Again, public health policy vs. science. Good science to wait to see if they work but catastrophically bad public policy that probably lead to the deaths of tens of thousands of people. And just like with the J&J pause this was 100% predictable ahead of time.
No this was a discussion regarding the timing of how long the efficacy studies would take. You kept repeating that there was: "Basic safety of the vaccines was (to the best of my knowledge) established by the end of summer 2020. At this time there was also very promising data on efficacy." It simply didn't exist at that time nor would money have been the simple solution, unless you really want to have inoculated a million people for the initial study. Maybe would have been nice, but clinical trials of that size... it doesn't happen overnight or in months. Something the system can build towards the future, I really hope for.

Regarding manufacturing, I already said "Yeah, so your concern is at the policy level, not the science level."

No one has ever argued for discounting the potential for negative outcomes, ever. Why would you say that? What the FDA failed to do is the same thing the CDC failed to do, which was appropriately account for the risk/reward ratio of their guidance. They went minimum risk from medical intervention when good public health policy was screaming to do the opposite. See how my point about making your best guess applies here? We didn't know for sure but I made a guess based on the available evidence and I was right while the FDA waited for more certainty and probably indirectly led to the deaths of large numbers of people.

Interesting enough, I have posted about your discounting numerous times the negative outcomes regarding masking, vaccines, and vaccine safety. In masking, I've already spoken to the issue regarding concerns of self-inoculation of contaminated masks and the potential of potentiation of infection by masking. These are real aspects the policy makers considered, but you are more than willing to disregard them on your quest to show how surgical masking was of value back in March 2020. Just because those negative possibilities didn't occur, they were important variables in the calculus of the time. And point repeatedly is that you have to consider these potential outcomes.
While you made a clear error here in accusing me of something that even a cursory search would have shown was inaccurate I'm not going to keep rubbing your face in it. I respect you and so I've made a point of being civil and it would be nice if you would return the favor. There's no need to talk shit to me here and it's okay if we just don't agree on the proper risk/reward profile. I think you're clearly wrong, but you're not crazy.

LOL! What did I claim? You can still Monday Morning Quaterback a decision even if you predicted a particular outcome, especially when a critical piece of information was an unknown. You and me neither had information about the extent of the number of blood clots in the world regarding the J&J vaccine. That was the point of the pause, to address that very question. I'm glad it really stayed a one in a million event as you predicted. But I also acknowledge the very real possibility it could have been something greater. Did you? On what basis? As I already mentioned, I didn't like the J&J pause .
 

fskimospy

Elite Member
Mar 10, 2006
88,236
55,790
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No its pretty clear I hit nail on the head. Your posts reflect how you haven't been objective whatsoever regarding this topic and is the downfall of any assertions you've made. You felt the CDC made some nefarious decision about masking, and have continually changed your assertion to somehow continual modification of what you claimed the CDC actually did.

Anybody looking at the situation from an objective lens would have asked, how and why did the CDC make the decision they did? I looked at the science. At the time, it was felt that only those who were symptomatic spread the virus and the number of asymptomatic spreaders was not a major part of the equation. Apparently you have no concerns of those presumptions as you have not disagreed with them. Then I examined the reality of how the CDC and the WHO approaches these situations with a risk-based approach. There has been 20+ years of this approach. There has never been a policy towards actually endorsing universal masking. And then I looked at the actual data to support who should mask and who doesn't need to and why these organizations made their recommendations. And you've agreed! There's evidence to support masking healthcare workers but not the general public. Then you brought into public policy and I mentioned the critical mask shortage, and the feasibility of changing the recommendation. All of these variables played into the calculus, and makes the CDC's position justifiable. There is no information, data, or even argument you've presented that the CDC shouldn't have continued their risk-based approach, it was only later did we learn that the science was incomplete. But the CDC took their best guess as you want them to.

Sigh, no they didn’t and there’s no point in repeating myself again.

And that's the position I have stuck to throughout, and now you annoyed with me pointing out the numerous flaws and inconsistencies of your logic. I'm more than happy to keep on pointing out more of your inconsistencies, don't try to project your feelings onto me.

I’m not annoyed in the slightest and you haven’t pointed out any inconsistencies. It’s very clear you are though as you’ve repeatedly tried to attribute to me positions I don’t hold, implied that I’m insane, etc. It’s okay if you’re frustrated, but again I think you might want to take a step back and question if you’re mad because I’m right.

Nope. Please don't try to rewrite what you said. You said very clearly: "This comes back to my original point though, which is that prioritizing them for health workers made sense but I think if that’s the goal you just say that’s the goal. In terms of actual cost to an individual and society wearing a mask costs essentially zero."

No where in that "original point" do you acknowledge what they said regarding masks should be for healthcare workers, nor do you write about commentary about effectiveness.
I have never criticized the CDC’s statements prioritizing health care workers. This is another case of you attributing positions to me that I have never held. You shouldn’t do this.

In fact, they did exactly what you wanted. Now you are just trying to rewrite what you said. You mentioned bad faith arguments, correct?

They did not do exactly what I wanted, as we have discussed repeatedly. Here you are now accusing me of being dishonest, which is childish. You should stop.

That's quite a strawman. I'm still waiting for a complete argument as to why the CDC should have dropped their practice of risk-based masking. You've made the assertion, all I've seen now is they should have used their best guess! Well they did, they chose risk-based masking. But saying they should guess the other way not on the basis of any legitimate concern is not a persuasive argument to anyone, as that would mean to ignore precedence, to ignore science, and to ignore the realities of the mask stock.
Sigh.

I agree, it shows that reading scientific papers is not as easy as it seems. Please answer for all of us, what was the authors primary hypothesis in studies 2 and 4 as this describes their "intention to treat" analysis. As in, the authors hypothesized that masks would _________. Please fill in the blank for their primary endpoint. I am being very precise in my language because you have been very loosey-goosey. Did the authors accept or reject their hypothesis for the primary outcome?
This is a continuing example of the blind spot I’ve discussed.

I understand the conclusions of the papers perfectly well, but several of them support my position. Instead of grappling with this you’re ignoring it, presumably because you have no answer and don’t want to back down.
Nope. You now agree there's no clear evidence to support universal masking.
And as I have repeatedly reminded you, clear evidence is not necessary in an emergency. It’s the difference between science and public health policy.

There was evidence that masks are effective at preventing infection and issues with masking outside of a health care setting are the types of issues present in other interventions that public health campaigns routinely address. As I’ve said, the right answer was not to say that masks were ineffective, because that’s not what the science said as shown by your own links.

Again, imagine my condom example. I imagine you did not address it because you know I’m right.
Hydroxychloroquine continued well into early May. But most hospitals moved away from using hydroxychloroquine before the major clinical trials were completed. So that's not how it happened.

But the point, again, is that decisions can have consequences, some with major negative outcomes. As discussed below, you're very much happy to railroad over those possibilities especially when it comes to masking.

This is again inventing a position I do not hold.

Saying we discussed it when you never discussed it isn't an argument. I'm sorry. There were 30 million masks in the national stockpile, how could have that supply been sufficient for healthcare workers and the general public if they followed what you wanted to recommend? This is a question of feasibility of what you want, and interestingly enough you won't address. How would it have been feasible with that supply?

I’m confused as to what you think I wanted or why your point here is relevant. I supported restricting masks to health care workers but I did not support the CDC saying masks were ineffective when there was considerable reason to believe this was not true.

Why would you care about the publication date? Instead of actually addressing how the CDC reacted to changing information, you are more concerned about a publication date and not knowing what the CDC did. Well, that's one way to not address what I said.


No this was a discussion regarding the timing of how long the efficacy studies would take. You kept repeating that there was: "Basic safety of the vaccines was (to the best of my knowledge) established by the end of summer 2020. At this time there was also very promising data on efficacy." It simply didn't exist at that time nor would money have been the simple solution, unless you really want to have inoculated a million people for the initial study. Maybe would have been nice, but clinical trials of that size... it doesn't happen overnight or in months. Something the system can build towards the future, I really hope for.
This is untrue.

Armed with the knowledge that I was right about this have you reconsidered your position?

From your arguments about the vaccine in particular I get the impression you do not have any experience with public policy because what you’re saying here makes no sense from a policy perspective.

Regarding manufacturing, I already said "Yeah, so your concern is at the policy level, not the science level."
Of course - this is a public policy discussion.


Interesting enough, I have posted about your discounting numerous times the negative outcomes regarding masking, vaccines, and vaccine safety. In masking, I've already spoken to the issue regarding concerns of self-inoculation of contaminated masks and the potential of potentiation of infection by masking. These are real aspects the policy makers considered, but you are more than willing to disregard them on your quest to show how surgical masking was of value back in March 2020. Just because those negative possibilities didn't occur, they were important variables in the calculus of the time. And point repeatedly is that you have to consider these potential outcomes.
I have never discounted those risks and you know this. Please stop inventing positions for me to hold.

LOL! What did I claim? You can still Monday Morning Quaterback a decision even if you predicted a particular outcome, especially when a critical piece of information was an unknown. You and me neither had information about the extent of the number of blood clots in the world regarding the J&J vaccine. That was the point of the pause, to address that very question. I'm glad it really stayed a one in a million event as you predicted. But I also acknowledge the very real possibility it could have been something greater. Did you? On what basis? As I already mentioned, I didn't like the J&J pause .
I have to say this is a new one, haha. ‘You Monday morning quarterbacked a decision by contemporaneously criticizing it and entirely accurately predicting why it would be bad.’ Lol. You’re being ridiculous. I’m mature enough to admit when I’ve made a mistake, you should be too. Just say ‘I was wrong’ and move on. I won’t lord it over you, and you might even find it liberating.

Regardless, you’re repeating the same stuff and continually attributing positions to me that I don’t hold, which is getting tiresome. I wish it were possible to have a more productive discussion with you on this topic but that doesn’t seem to be in the cards. You can feel free to have the last word.
 

abj13

Golden Member
Jan 27, 2005
1,071
902
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This is untrue.

Armed with the knowledge that I was right about this have you reconsidered your position?

That's really unfortunate. If you are going to put the time into a reply, you really should have thought out your responses. Not only did you fail to demonstrate why the CDC should not have made their risk based approach for masking, attempt to change what you said, failure to understand the primary outcome of two research studies, failure to explain how surgical mask demand could be met with a 30 million supply, but this one really takes the cake.

I really suggest you delete that portion of your post. This is quite embarrassing that you took the time to Google something and not quite understand what you posted, much like the trials regarding masking.

Both Pfizer press releases demonstrate that those in their phase I trial developed antibodies to the vaccine. Great! So does pretty much every health human when you inject a non-human protein, or even mRNA into him/her. They then took the blood, and the serum of the subjects neutralized the virus in cell culture. Great, these antibodies might be meaningful! They also tolerated the injection. Great!

Ok anything else?

That's it.

Your press releases offer no efficacy in the vaccine protecting the subject against infection. Does the antibodies they developed actually protect them for any outcome? Do they mean anything in the real world to real people? No data about PCR positivity. No data regarding hospitalization. No data regarding death. No information regarding whether the vaccine could cause 1 in 100 major adverse events. Nothing.

And to top if off, no vaccinologist would be reassured by the data presented. Why? People with essential knowledge about vaccine will tell you that not only does clinical efficacy matter, but the major safety concern was antibody-dependent-enhancement. This is why the RSV vaccine failed and led to deaths in the trials. This is why vaccines against Dengue, SARS-CoV-1 and MERS failed at different stages. Yes, other coronavirus vaccines failed at various stages because of this issue. This was a major concern regarding the vaccine. This topic was sprinkled throughout 2020, including discussions in the Scientist in May and many other news stories.

Guess what? None of that data provides any reassurance for or against it. So you have no data regarding efficacy. No data about protection from disease, hospitalization, or death. No conclusions can be made about significant adverse events that occur at the level of 1-5%. No data to suggest safety from antibody-dependent-enhancement. To suggest this is adequate data for vaccine development, and people should change their position based on it, well, you should delete it.


Have a good weekend!
 
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fskimospy

Elite Member
Mar 10, 2006
88,236
55,790
136
That's really unfortunate. If you are going to put the time into a reply, you really should have thought out your responses. Not only did you fail to demonstrate why the CDC should not have made their risk based approach for masking, attempt to change what you said, failure to understand the primary outcome of two research studies, failure to explain how surgical mask demand could be met with a 30 million supply, but this one really takes the cake.

I really suggest you delete that portion of your post. This is quite embarrassing that you took the time to Google something and not quite understand what you posted, much like the trials regarding masking.

Both Pfizer press releases demonstrate that those in their phase I trial developed antibodies to the vaccine. Great! So does pretty much every health human when you inject a non-human protein, or even mRNA into him/her. They then took the blood, and the serum of the subjects neutralized the virus in cell culture. Great, these antibodies might be meaningful! They also tolerated the injection. Great!

Ok anything else?

That's it.

Your press releases offer no efficacy in the vaccine protecting the subject against infection. Does the antibodies they developed actually protect them for any outcome? Do they mean anything in the real world to real people? No data about PCR positivity. No data regarding hospitalization. No data regarding death. No information regarding whether the vaccine could cause 1 in 100 major adverse events. Nothing.

And to top if off, no vaccinologist would be reassured by the data presented. Why? People with essential knowledge about vaccine will tell you that not only does clinical efficacy matter, but the major safety concern was antibody-dependent-enhancement. This is why the RSV vaccine failed and led to deaths in the trials. This is why vaccines against Dengue, SARS-CoV-1 and MERS failed at different stages. Yes, other coronavirus vaccines failed at various stages because of this issue. This was a major concern regarding the vaccine. This topic was sprinkled throughout 2020, including discussions in the Scientist in May and many other news stories.

Guess what? None of that data provides any reassurance for or against it. So you have no data regarding efficacy. No data about protection from disease, hospitalization, or death. No conclusions can be made about significant adverse events that occur at the level of 1-5%. No data to suggest safety from antibody-dependent-enhancement. To suggest this is adequate data for vaccine development, and people should change their position based on it, well, you should delete it.


Have a good weekend!
You really might want to take some more time to think about this because this post is showing embarrassing levels of public policy incompetence.

I really am done now but if you don’t understand why we should have been mass manufacturing every plausible vaccine even if we had literally zero evidence of efficacy or even basic safety you are showing you don’t understand the problem.
 

abj13

Golden Member
Jan 27, 2005
1,071
902
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You really might want to take some more time to think about this because this post is showing embarrassing levels of public policy incompetence.

LOL! Your links show no evidence of efficacy at the level of infection, hospitalization, or death, no evidence safety from major adverse events that occur less frequently, and to top it off, no data regarding safety from antibody-dependent enhancement, really, what did you actually think the meaning of those links were?

This is what happens when you rush to post and have completely given up objectivity. I'll give you a second chance to delete that portion of your post.

Ah yes, the stealth edit you inserted:
I really am done now but if you don’t understand why we should have been mass manufacturing every plausible vaccine even if we had literally zero evidence of efficacy or even basic safety you are showing you don’t understand the problem.

Where did I say we shouldn't start manufacturing before the vaccines were approved? I said we shouldn't implement (use them in the general population) until the vaccine safety and efficacy was established here and here.

Citation please. Its quite sad to see you become so intellectually dishonest in this discussion.
 
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Bitek

Lifer
Aug 2, 2001
10,676
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You must have pulled that 100M infections out of your know where. I double checked and CDC numbers of confirmed cases are 32M. And dont forget, some of the people who were infected also have gotten the vaccine, so may be double counted.

And yes, you are right. 70% is an "estimate" for herd immunity. However, that is probably a minimum estimate. I have seen other estimates of 80%. Covid can also be spread among subjects who are too young to qualify for the vaccine.

Bottom line though, why is it such a burden to you to just wear a damn mask? If wearing a mask nationwide can save even 10,000 or 50k or 100k until the virus is better suppressed, is it really that much of a burden to your "rights" for you and your fellow anti-maskers to show that much consideration to the right of others to simply live or avoid a serious hospital stay and possible long term covid effects?

And as for the hillbilly states having the virus under control while ignoring the science, India is calling you.

It's right on the CDC site, look at the seroprevalence data.




The 32M case figure is confirmed PCR positivity, but it's known that this is an undercount. Not everyone who gets ill gets tested, either due to not bothering, lack of access, or is asymptomatic.

However, by testing random blood samples, the CDC can detect antibodies, and model out the a more realistic figure. It's about 3x higher, ie, 100M

The real question is tho, what are the triggers and victory conditions you are looking for? What incentive is there to get vaccinated if there will never be a return to normal?

Vaccines are highly effective
Overall immunity rate is high
Rates are very low and still falling
PPE IS THE LEAST EFFECTIVE SAFETY CONTROL
Requirements for ventilation and other more effective engineering, etc controls are still recommended.
HierarchyControls.jpg


The "rights" issue is your words, not mine. I am a blue voter, but I'm also a professional scientist, and have a lot of professional responsibility with this issue.

The left will need to also look past politics and the Trump era lies on this issue, and the counter reaction, and really follow the science and experts if we are to successfully navigate out of the pandemic and restore the full economy.
 
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eelw

Lifer
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Even if that many people were infected, studies still showing immune response from having covid still isn't as good as vaccine. So wouldn't hold hope those individuals will help with herd immunity.
 

pmv

Lifer
May 30, 2008
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At the time, it was felt that only those who were symptomatic spread the virus and the number of asymptomatic spreaders was not a major part of the equation.

I'm jumping in to the middle of an argument I haven't followed (between you and fskimospy), because it relates to my own gripe (albeit yesterdays' gripe that I'd long since forgotten about) about how the advice on masking suddenly changed in this country (the UK).

The key word there seems to be "felt". Since when were feelings an appropriate basis for policy on something like this?

Here they told us quite explicitly not to bother with masks, right up to the point when they suddenly changed their mind. Sure, before they didn't realise how common asymptomatic spread was - but that still makes it questionable for them to have given such definitive advice (i.e. don't get a mask) when they hadn't actually done the research or looked at the data yet.

To me that is 'symptomatic' of a wider issue with 'experts' tendency to be over-definitive when talking to laypeople about their conclusions, and their reluctance to admit they don't yet know something.

The honest thing to have said before the information on asymptomatic spread was known was "we don't really know yet, because the studies haven't been done, we'll get back to you". Instead they went with "masks won't help, don't use them". Reminds me of all the doctors who have made definitive statements to me about things where I knew they were wrong (usually in an attempt to reassure my health anxieties - whether those anxieties were indeed irrational is beside the point - bluff and bluster doesn't help in such cases).

I feel it is an example of a general problem with experts being overly-reluctant to acknowledge a lack of knowledge about a topic, and it always just ends up damaging their credibility when they go beyond what they actually know, like that.
 
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abj13

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However, by testing random blood samples, the CDC can detect antibodies, and model out the a more realistic figure. It's about 3x higher, ie, 100M

Maybe, I'm missing it from your links, but where does it say 3x? Some of those data sources only go into the Summer of 2020 in your link, when you look at the larger CDC national seroprevalence data, most states range from 10-30% seropositivity. Having a 100M cases would suggest the seropositivity would be 30+% for most states. Is there something I didn't find on that page?

Our own local data using an assay independent of the CDC showed there was a massive undercount in May 2020 (~5x), but by January, PCR testing was undercounting serology by 1.3-1.5x. So it is very time dependent as you said, testing improved over time narrowing the discordance in the rates. Surprisingly, the seroprevalence of children was almost the same compared to adults. Clearly children don't react the same way to the virus.
 

abj13

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Jan 27, 2005
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I'm jumping in to the middle of an argument I haven't followed (between you and fskimospy), because it relates to my own gripe (albeit yesterdays' gripe that I'd long since forgotten about) about how the advice on masking suddenly changed in this country (the UK).

The key word there seems to be "felt". Since when were feelings an appropriate basis for policy on something like this?

Here they told us quite explicitly not to bother with masks, right up to the point when they suddenly changed their mind. Sure, before they didn't realise how common asymptomatic spread was - but that still makes it questionable for them to have given such definitive advice (i.e. don't get a mask) when they hadn't actually done the research or looked at the data yet.

To me that is 'symptomatic' of a wider issue with 'experts' tendency to be over-definitive when talking to laypeople about their conclusions, and their reluctance to admit they don't yet know something.

The honest thing to have said before the information on asymptomatic spread was known was "we don't really know yet, because the studies haven't been done, we'll get back to you". Instead they went with "masks won't help, don't use them". Reminds me of all the doctors who have made definitive statements to me about things where I knew they were wrong (usually in an attempt to reassure my health anxieties - whether those anxieties were indeed irrational is beside the point - bluff and bluster doesn't help in such cases).

I feel it is an example of a general problem with experts being overly-reluctant to acknowledge a lack of knowledge about a topic, and it always just ends up damaging their credibility when they go beyond what they actually know, like that.

Felt. Presumed on the basis of other viruses. Inferrred from other viruses. Its a word choice I used for brevity. I wouldn't get too hung up on it. Happy to correct it if you want.

But yes, at the time, the risk factors that were known for getting COVID-19 was exposure to someone with COVID-19. While the extent of transmission of COVID-19 was unknown at the time, there was clear precedent that with other respiratory viruses, transmission in the presymptomatic or asymptomatic phase did not lead to superspreader events or was a major route of transmission. So this isn't some presumption but there was very much real scientific support for this presumption/inference/any other term you want to use. This publication reviewed the data in 2009 regarding influenza, and they found: "Based on the available literature, we found that there is scant, if any, evidence that asymptomatic or presymptomatic individuals play an important role in influenza transmission." So while transmission can occur, its not a major route by which people are infected, rather, it is exposure to those actively symptomatic.

So yes, while influenza is a different virus, what are you going to base a decision on when you don't have data in regards to SARS CoV-2? And this is true for many other viruses. Ebola is the one most people are aware of, you don't transmit it until you are symptomatic. How did we contain the original SARS-CoV-1 outbreak? It was using risk based masking, not everyone masking up. The multitude of publications showed that the risk factor for the original SARS outbreak was exposure to someone with it. That's how they could trace 80% of the cases of SARS in Hong Kong back to one of the original superspreaders.

So while there any data at that point in time regarding the viral dynamics of SARS-CoV-2 (asymptomatic infection and transmission), there was legitimate data regarding other viruses including Influenza and SARS-CoV-1, data regarding universal masking of having no clear benefit with very real risks, and supply issues that would have pushed the CDC to maintain their risk-based masking. It was already clear that exposure to someone with COVID-19 was a major risk factor for transmission. That's specifically what Fauci spoke to in the 60 Minutes interview. Put the masks on people who are exposed to people with COVID-19.

Sure everyone can look back on that decision now with the data we have now and and say it was a wrong decision, but people wanted the CDC to make their "best guess." Would you discount the data regarding influenza and SARS-CoV-1?
 

fskimospy

Elite Member
Mar 10, 2006
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I'm jumping in to the middle of an argument I haven't followed (between you and fskimospy), because it relates to my own gripe (albeit yesterdays' gripe that I'd long since forgotten about) about how the advice on masking suddenly changed in this country (the UK).

The key word there seems to be "felt". Since when were feelings an appropriate basis for policy on something like this?

Here they told us quite explicitly not to bother with masks, right up to the point when they suddenly changed their mind. Sure, before they didn't realise how common asymptomatic spread was - but that still makes it questionable for them to have given such definitive advice (i.e. don't get a mask) when they hadn't actually done the research or looked at the data yet.

To me that is 'symptomatic' of a wider issue with 'experts' tendency to be over-definitive when talking to laypeople about their conclusions, and their reluctance to admit they don't yet know something.

The honest thing to have said before the information on asymptomatic spread was known was "we don't really know yet, because the studies haven't been done, we'll get back to you". Instead they went with "masks won't help, don't use them". Reminds me of all the doctors who have made definitive statements to me about things where I knew they were wrong (usually in an attempt to reassure my health anxieties - whether those anxieties were indeed irrational is beside the point - bluff and bluster doesn't help in such cases).

I feel it is an example of a general problem with experts being overly-reluctant to acknowledge a lack of knowledge about a topic, and it always just ends up damaging their credibility when they go beyond what they actually know, like that.
Yeah, my issue is similar. They knew masks are effective at blocking transmission, that’s why they wanted them for health care workers, after all! The issue was that they weren’t sure if they would be helpful generally and so they wanted to save them for those they would help most. Instead of just saying that, in addition they actively discouraged their use and this came back to bite us all because they had permanently undermined their credibility.

I have been frankly shocked at the total inability of public health organizations to understand the public or how to implement effective public health policy. People react emotionally and usually only pay limited attention to what’s being said anyway, once you’ve created an information shortcut for them where you can’t be trusted, it’s game over. Like with the J&J pause I’m sure the FDA really did think that the public would see them pausing distribution to analyze more data to ensure safety and come away reassured. It did not seem to dawn on them that the vastly more likely outcome was people coming away with the idea the vaccine was unsafe and refusing to take it. (Or, they didn’t care because they wouldn’t be blamed for those deaths)
 
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pmv

Lifer
May 30, 2008
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PPE IS THE LEAST EFFECTIVE SAFETY CONTROL
Requirements for ventilation and other more effective engineering, etc controls are still recommended.
HierarchyControls.jpg


Wish all that would be remembered when cyclists are told to wear helmets and high-viz! [/off-topic]


Felt. Presumed on the basis of other viruses. Inferrred from other viruses. Its a word choice I used for brevity. I wouldn't get too hung up on it. Happy to correct it if you want.

But yes, at the time, the risk factors that were known for getting COVID-19 was exposure to someone with COVID-19. While the extent of transmission of COVID-19 was unknown at the time, there was clear precedent that with other respiratory viruses, transmission in the presymptomatic or asymptomatic phase did not lead to superspreader events or was a major route of transmission. So this isn't some presumption but there was very much real scientific support for this presumption/inference/any other term you want to use. This publication reviewed the data in 2009 regarding influenza, and they found: "Based on the available literature, we found that there is scant, if any, evidence that asymptomatic or presymptomatic individuals play an important role in influenza transmission." So while transmission can occur, its not a major route by which people are infected, rather, it is exposure to those actively symptomatic.

So yes, while influenza is a different virus, what are you going to base a decision on when you don't have data in regards to SARS CoV-2? And this is true for many other viruses. Ebola is the one most people are aware of, you don't transmit it until you are symptomatic. How did we contain the original SARS-CoV-1 outbreak? It was using risk based masking, not everyone masking up. The multitude of publications showed that the risk factor for the original SARS outbreak was exposure to someone with it. That's how they could trace 80% of the cases of SARS in Hong Kong back to one of the original superspreaders.

So while there any data at that point in time regarding the viral dynamics of SARS-CoV-2 (asymptomatic infection and transmission), there was legitimate data regarding other viruses including Influenza and SARS-CoV-1, data regarding universal masking of having no clear benefit with very real risks, and supply issues that would have pushed the CDC to maintain their risk-based masking. It was already clear that exposure to someone with COVID-19 was a major risk factor for transmission. That's specifically what Fauci spoke to in the 60 Minutes interview. Put the masks on people who are exposed to people with COVID-19.

Sure everyone can look back on that decision now with the data we have now and and say it was a wrong decision, but people wanted the CDC to make their "best guess." Would you discount the data regarding influenza and SARS-CoV-1?

That's a rational defence, but I still am not convinced. This isn't the influenza virus, so why _presume_ it would behave the same way? And if you are making such a presumption as the basis for recommendations, maybe acknowledge that qualifier when you make those recommendations? Be open with people about the uncertainties and assumptions involved.

Also, I wonder if the issue isn't also about the difference between actual research scientists and those whose job it is to communicate such findings to the public? The latter don't seem to always keep up with the latest work of the former, and will confidently tell the public something that isn't in fact supported by the most recent data. Excessive certainty in statements just seems counter-productive, is all.
 

fskimospy

Elite Member
Mar 10, 2006
88,236
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Wish all that would be remembered when cyclists are told to wear helmets and high-viz! [/off-topic]




That's a rational defence, but I still am not convinced. This isn't the influenza virus, so why _presume_ it would behave the same way? And if you are making such a presumption as the basis for recommendations, maybe acknowledge that qualifier when you make those recommendations? Be open with people about the uncertainties and assumptions involved.

Also, I wonder if the issue isn't also about the difference between actual research scientists and those whose job it is to communicate such findings to the public? The latter don't seem to always keep up with the latest work of the former, and will confidently tell the public something that isn't in fact supported by the most recent data. Excessive certainty in statements just seems counter-productive, is all.
Well, it’s an emergency and you have to act with the information you have so that requires making your best guess based on that information. Yes though, public health agencies should acknowledge that uncertainty to maintain their own credibility so if you really do need to push people to do something you have a better chance of them listening.
 

abj13

Golden Member
Jan 27, 2005
1,071
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That's a rational defence, but I still am not convinced. This isn't the influenza virus, so why _presume_ it would behave the same way? And if you are making such a presumption as the basis for recommendations, maybe acknowledge that qualifier when you make those recommendations? Be open with people about the uncertainties and assumptions involved.

It wasn't just Influenza. I also mentioned the most closely related virus to SARS-CoV-2, the dynamics of SARS-CoV-1 was truly spread of the virus by symptomatic people. If it wasn't, well, the past year's event would have happened back in 2003-2004.

But pick your poison. How long would have Fauci needed in the 60 Minutes interview to talk about the transmission dynamics, what is known about other viruses, how the CDC has taken a risk-based strategy for all other situations incluiding H1N1, the data behind why masking makes sense in healthcare workers, how there was no clear evidence in support of universal masking, the risks associated with masking, and the current supply status... who would have listened to that?

People look to experts to be experts, to find a way to distill knowledge into meaningful statements that don't require citations after every sentence. But that's why the CDC puts out, IMO, well detailed webpages, so people can look at the ideas and concepts in a more detailed way.

Also, I wonder if the issue isn't also about the difference between actual research scientists and those whose job it is to communicate such findings to the public? The latter don't seem to always keep up with the latest work of the former, and will confidently tell the public something that isn't in fact supported by the most recent data. Excessive certainty in statements just seems counter-productive, is all.
So are you saying research scientists should communicate science with the public? What's your feeling about Fauci then? He's an author on over a 1,000 publications(!!!). His early clear before leading NIAID was one of the top immunology researchers, who then became a leader in HIV. He's really done it all.
 

Bitek

Lifer
Aug 2, 2001
10,676
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It's right on the CDC site, look at the seroprevalence data.




The 32M case figure is confirmed PCR positivity, but it's known that this is an undercount. Not everyone who gets ill gets tested, either due to not bothering, lack of access, or is asymptomatic.

However, by testing random blood samples, the CDC can detect antibodies, and model out the a more realistic figure. It's about 3x higher, ie, 100M
Maybe, I'm missing it from your links, but where does it say 3x? Some of those data sources only go into the Summer of 2020 in your link, when you look at the larger CDC national seroprevalence data, most states range from 10-30% seropositivity. Having a 100M cases would suggest the seropositivity would be 30+% for most states. Is there something I didn't find on that page?

Our own local data using an assay independent of the CDC showed there was a massive undercount in May 2020 (~5x), but by January, PCR testing was undercounting serology by 1.3-1.5x. So it is very time dependent as you said, testing improved over time narrowing the discordance in the rates. Surprisingly, the seroprevalence of children was almost the same compared to adults. Clearly children don't react the same way to the virus.

It's on there, there are a couple of studies, but the site is not playing nice with my phone. Idk how good the data will be now with widespread vaccination, eg if the tests they use can discriminate.
 

Bitek

Lifer
Aug 2, 2001
10,676
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Wish all that would be remembered when cyclists are told to wear helmets and high-viz! [/off-topic]

Not cycling at all would be the safest :) (eliminate the hazard)

But life is not risk free, so we must make rational choices. Not everyone's risk valuations safe the same, hence the controversy.
 
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ondma

Diamond Member
Mar 18, 2018
3,319
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It's right on the CDC site, look at the seroprevalence data.




The 32M case figure is confirmed PCR positivity, but it's known that this is an undercount. Not everyone who gets ill gets tested, either due to not bothering, lack of access, or is asymptomatic.

However, by testing random blood samples, the CDC can detect antibodies, and model out the a more realistic figure. It's about 3x higher, ie, 100M

The real question is tho, what are the triggers and victory conditions you are looking for? What incentive is there to get vaccinated if there will never be a return to normal?

Vaccines are highly effective
Overall immunity rate is high
Rates are very low and still falling
PPE IS THE LEAST EFFECTIVE SAFETY CONTROL
Requirements for ventilation and other more effective engineering, etc controls are still recommended.
HierarchyControls.jpg


The "rights" issue is your words, not mine. I am a blue voter, but I'm also a professional scientist, and have a lot of professional responsibility with this issue.

The left will need to also look past politics and the Trump era lies on this issue, and the counter reaction, and really follow the science and experts if we are to successfully navigate out of the pandemic and restore the full economy.
Yea, like ABJ 13, I couldn't find that 100 million seropositive data either in the pages you linked. Admittedly the site is very confusing, and I eventually gave up. Can you link the specific page that shows that? In any case, simply being seropositive is not proven to be as effective as vaccination.

To answer your question, before lifting the mask mandate, I would like to see vaccination extended to 12+ age group (I think that is starting now, at least with one manufacturer) and 75 to 80 percent of the population (over 12) vaccinated. I agree with lifting restrictions outdoors, my problem is with basically lifting the indoor mandate for everywhere except for a few places like health care settings and transportation facilities. And lets face the facts, expecting those not vaccinated to use the "honor system" and keep wearing masks is absurd. It simply is not going to happen. If one does not have the personal responsibility to get vaccinated, they certainly will not have the responsibility to voluntarily mask up. In fact, I would bet that the people continuing to wear masks voluntarily will mostly be made up of those already vaccinated, but who take the virus seriously, and wish to "err" on the side of caution in preventing the spread.

Regarding "Hierarchy of Controls" diagram; it doesn't even seem to be specifically geared to covid, but wearing a mask obviously would be a step toward the "most effective" step, i.e. physically removing the hazard (i.e. less covid carrying materials in the atmosphere).
 
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soundforbjt

Lifer
Feb 15, 2002
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I heard yesterday that only 44% of Congressional republicans are fully vaccinated, pandering to their base in the worst ways.
 

abj13

Golden Member
Jan 27, 2005
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It's on there, there are a couple of studies, but the site is not playing nice with my phone. Idk how good the data will be now with widespread vaccination, eg if the tests they use can discriminate.

Tableau is such a pain. I made an infographic using it last year, getting it to work across phone/tablet/computer was where I spent the majority of my time.

I also looked at the footnotes publications. The JAMA IM publication showed a 6-24x discordance between serology and PCR, but that was based on samples from March-May 2020, but clearly surges and the shortage of testing played into that. I didn't see anything showing 3x, but let me know, I'm curious to see the contrast between our local data.
 
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pmv

Lifer
May 30, 2008
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Not cycling at all would be the safest :) (eliminate the hazard)

But life is not risk free, so we must make rational choices. Not everyone's risk valuations safe the same, hence the comments.

The diagram as given would suggest you should either "isolate people from the hazard", i.e. have separate roads for cycling and motorised vehicles, "replace the hazard" i,.e replace motorised vehicles with bicycles (or something else), or "physically remove the hazard" i.e. ban cars from public roads.
 

weblooker2021

Senior member
Jan 18, 2021
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I am in Los Angeles that still got mask mandate ,today in Lowes while i was getting some items, i saw at least 8 people without a mask. It appears regardless whatever local mandate that still exist,that some public is done with wearing mask one way or another.
 

Fenixgoon

Lifer
Jun 30, 2003
33,595
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I am in Los Angeles that still got mask mandate ,today in Lowes while i was getting some items, i saw at least 8 people without a mask. It appears regardless whatever local mandate that still exist,that some public is done with wearing mask one way or another.
Some people never wore masks to begin with, so that's not really a powerful observation

I saw plenty of people without masks throughout the past year with mask mandates in place in my state (MD), and I absolutely considered them all to be assholes with no regard for the fellow citizens.
 

fskimospy

Elite Member
Mar 10, 2006
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Some people never wore masks to begin with, so that's not really a powerful observation

I saw plenty of people without masks throughout the past year with mask mandates in place in my state (MD), and I absolutely considered them all to be assholes with no regard for the fellow citizens.
The internet is inundated with videos of morons in various businesses fighting with the staff about masks.

I think my favorite one though was where that white supremacist Baked Alaska was harassing the staff and refusing to wear a mask so they called the cops. He folded instantly and tried to leave, only to realize it was too late for that and he was going to be arrested. It was hilarious.
 
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Fenixgoon

Lifer
Jun 30, 2003
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The internet is inundated with videos of morons in various businesses fighting with the staff about masks.

I think my favorite one though was where that white supremacist Baked Alaska was harassing the staff and refusing to wear a mask so they called the cops. He folded instantly and tried to leave, only to realize it was too late for that and he was going to be arrested. It was hilarious.

that is gold :D