Larrelarre: Are you using Fraps to measure the FPS? I have a licensed version (up to 3.5) and it does a very nice job. If you were going from a 580 GTX to a 680 I could see the anamoly but not a 460 GTX. Like the other posters, I think it has to do with the different settings. Some games automatically adjust when a new video card is installed and set different parameters. Though tedious, did you write down EVERY graphics parameter for Borderelands and compare each one to assure they were exactly the same for the 460 GTX vs the 680 GTX ?