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Got my genetic testing results

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Brainonska511 said:
How did the OP get scammed?
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is there any verification that you can get legitimate test results for 100 dollars for that wide an array of tests?

it is just really doubtful
http://rebeccaskloot.blogspot.com/2006/08/totally-nailed-home-dna-tests-ruled.html
"Since this investigation was done by a committee with no actual enforcement power, the end result of all this is a recommendation to the federal government that they require oversight of DNA testing, and a warning to consumers saying "a healthy dose of skepticism may be the best prescription," when dealing with these test results. May be? They've essentially been caught falsifying DNA results -- I'd say that warrants more than potential skepticism. I'm thinking that's grounds for full-fledged rejection. Good to keep in mind, since the companies are still operating in full force."

sounds like the fun of unregulated industry lol
 
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0roo0roo said:
is there any verification that you can get legitimate test results for 100 dollars for that wide an array of tests?

it is just really doubtful
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... wide an array of tests? I'm not even gonna get into this anymore. Google ftw..
 
iamanidiot said:
... wide an array of tests? I'm not even gonna get into this anymore. Google ftw..
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really? we do want to know if this is scientifically legitimate, go ahead, where is the independent verification that you didn't get scammed? all i've googled up is that these things are unregulated, and scammers have been found in the past, and the government has been powerless to do sh*t against it.
 
0roo0roo said:
really? we do want to know if this is scientifically legitimate, go ahead, where is the independent verification that you didn't get scammed? all i've googled up is that these things are unregulated, and scammers have been found in the past, and the government has been powerless to do sh*t against it.
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If it helps, the cost of a simple paternity test is in the $500-$1000 range. That's just to test if person A and person B are related (you is the father)!
If you want to compare individual parts of it and risk of diseases, one would think it would at least be as expensive as a paternity test.


That doesn't mean the OP got ripped off. It just seems probable. Like if he told us he bought a two bedroom house in Manhattan for $300,000 but he hasn't actually seen the property, the same red flags would go up.
 
0roo0roo said:
really? we do want to know if this is scientifically legitimate, go ahead, where is the independent verification that you didn't get scammed? all i've googled up is that these things are unregulated, and scammers have been found in the past, and the government has been powerless to do sh*t against it.
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Burden of proof falls on accuser. The inquirer article is too vague to comment on. The 2nd link does not pertain to this particular test based on the date.

Idk what kind of googling you did but a quick search on my end shows some simple to more advanced reviews of the service and short reponse from the founder commenting on the accuracy of the test.

The consenus is that the results are not the most reliable since we don't have all the knowledge needed to attribute everything to genetics. BUT that does not mean the variations in the genome are innacurate. If you bothered to read my previous posts you would see that I had stated that was enough for me as I don't plan to place too much weight on the interpretations given.

http://www.chromosomechronicles.com...ina-platform-confirmed-by-comparing-siblings/

That also disproves your theory of the vast array of tests that they perform for a mere $100. All they do is translate your SNPs to readable format. This is cross matched to a database of known variables and the "test results" as you would call them are genereated by computers.
 
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ShawnD1 said:
If it helps, the cost of a simple paternity test is in the $500-$1000 range. That's just to test if person A and person B are related (you is the father)!
If you want to compare individual parts of it and risk of diseases, one would think it would at least be as expensive as a paternity test.


That doesn't mean the OP got ripped off. It just seems probable. Like if he told us he bought a two bedroom house in Manhattan for $300,000 but he hasn't actually seen the property, the same red flags would go up.
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Paternal testing = full genome sequencing = PCR = more man labor
23andme = SNP genotyping = SNP microarrays = less man labor

apples and oranges
 
iamanidiot said:
Burden of proof falls on accuser. The inquirer article is too vague to comment on. The 2nd link does not pertain to this particular test based on the date.

Idk what kind of googling you did but a quick search on my end shows some simple to more advanced reviews of the service and short reponse from the founder commenting on the accuracy of the test.

The consenus is that the results are not the most reliable since we don't have all the knowledge needed to attribute everything to genetics. BUT that does not mean the variations in the genome are innacurate. If you bothered to read my previous posts you would see that I had stated that was enough for me as I don't plan to place too much weight on the results given.

http://www.chromosomechronicles.com...ina-platform-confirmed-by-comparing-siblings/

That also disproves your theory of the vast array of tests that they perform for a mere $100. All they do is translate your SNPs to readable format. This is cross matched to a database of known variables and the "test results" as you would call them are genereated by computers.
Click to expand...

no, burden of proof falls on you if you want to believe what you bought wasn't a scam. you paid cash for something you want to believe is legit, you should be the one caring if you were had or not.
yay blog proofs?
http://www.genetic-future.com/2008/01/uk-controversy-over-23andme.html
 
0roo0roo said:
no, burden of proof falls on you if you want to believe what you bought wasn't a scam. you paid cash for something you want to believe is legit, you should be the one caring if you were had or not.
yay blog proofs?
http://www.genetic-future.com/2008/01/uk-controversy-over-23andme.html
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You linked to yet another vague article that pertains (I can only assume since it doesn't say) to the interpretations of the test, after I've made it clear what my intentions were with the results.

Are you also one of those people who believe in excessive warning labels on all products?
 
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0roo0roo said:
no, burden of proof falls on you if you want to believe what you bought wasn't a scam. you paid cash for something you want to believe is legit, you should be the one caring if you were had or not.
yay blog proofs?
http://www.genetic-future.com/2008/01/uk-controversy-over-23andme.html
Click to expand...

The part that they are considering useless and a "scam" is the predictive part of the SNP analysis. There's nothing wrong with the raw data (what his actual SNPs are), it's just that the interpretations of GWAS/SNP analysis are still not very clear.
 
I am finishing a PhD in biological anthropology and my research focus is the geospatial dynamics of adaptive and neutral alleles. So, I am very familiar with personal genomics technologies and data interpretation. The service 23andme provides is pretty incredible, imho, given how much phenotypic prediction we can now accomplish in such a short period of time for such low cost. A few comments:

Leros said:
but lactose intolerant and alcohol flush...
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The giveaway is dry earwax. That SNP is essentially nonexistent outside of north Asia, though it is present at low frequencies in some southern Asian populations. Lack of any malaria resistance alleles (some of which are at considerable frequencies in south Asians) implies the OP is north Asian.

FWIW the alcohol flushing reaction is the same SNP that confers resistance to esophageal squamous cell carcinoma; interesting they present that as two distinct 'tests.'

vi edit said:
I got a kick out of the "muscle type: Likely not a sprinter" response.

LOL!
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That's a reference to this SNP. The sprinter SNP is rare outside of sub-Saharan Africa.

iamanidiot said:
Paternal testing = full genome sequencing = PCR = more man labor
23andme = SNP genotyping = SNP microarrays = less man labor

apples and oranges
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Paternity testing does not require full genome sequencing. It typically requires a combination of STRs, microsatellites, and a few Mendelian markers.

kami333 said:
The part that they are considering useless and a "scam" is the predictive part of the SNP analysis. There's nothing wrong with the raw data (what his actual SNPs are), it's just that the interpretations of GWAS/SNP analysis are still not very clear.
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The data are what they are and are unlikely to be erroneous. The issue of personal genomics is that phenotypes can be both mono- and polygenic. For some things, like the dry earwax phenotype, or the ABO blood type, we know with near 100% accuracy what a person's phenotype is from their genotype. In other cases, like the Crohn's Disease phenotype, there are many loci that are associated with the phenotype, but we don't know for certain what a person's phenotype might be given specific data. Hence the variation in confidence assigned to the predictions.

I agree with the OP, in that the results can be interesting. Unfortunately, really understanding them requires at least upper-level undergraduate training in statistics and genetics. The information given by 23andme is solid, but how well can you explain anything that's cutting edge science to a layperson? The media reports on these companies, and what the companies themselves try to do, are ample evidence that there's a lot of room for the unscrupulous to exploit the ignorant in personal genomics.

Oh, btw OP, I am a homozygote for the CCR5-Δ32 variant that confers resistance to HIV. It doesn't mean I ride bareback. 😉
 
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Gigantopithecus said:
Oh, btw OP, I am a homozygote for the CCR5-Δ32 variant that confers resistance to HIV. It doesn't mean I ride bareback. 😉
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Lol that's still a great thing to have though. I've been told no asians have that trait. It's extremely rare regardless lol.
 
did it confirm what we all understaood to be true through your Avatar?

😀


oh, and yeah....if paternal testing required full genome sequencing...then no one would be doing that.

It's getting way faster and way cheaper, sure--our on-campus facility just rolled out Illumina's HiSeq at the start of this year. It takes between 5~14 days to complete reads on a full genome. The cheaper runs are currently about $1300 per read.

of course, assembly and analysis is an entirely different monster.


not that any of this is about assembly, really.
 
guyver01 said:
:hmm:
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Not+Sure+if+serious.jpg
 
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