I'm throwing in my two-cents here, waiting for MEMTEST86+ to go through several iterations on an E2180 setup.
I have an E2140 setup and an E2180 setup with the same, chump-change, low-end, marvelous little budget motherboard from Gigabyte (GA-73VM-S2).
Now - this thing uses a 610i nVidia chipset, but I believe the same parameters apply for the CPU's over-clocking. You'll have to experiment with your board's FSB limits in 1:1 settings.
FIRST, we've had a discussion on another recent thread in which I maintain that all of these CPUs are the same -- they came off the same assembly-line, from the same manufacturing process, and were then routed to a point where the CPU was "locked."
The E2140 multiplier is 8; the E2160 multiplier is 9; and the E2180 multiplier is 10.
Although INtel's cooler uses something that "looks like" a silver-based or diamond-based compound -- I say -- get some 90% isopropyl and wipe it clean. I urge you to take time to lap the IHS with 320-grit followed by 400- when the copper half-exposed, and then 600-grit to get all the nickel-plating off.
VERY FREAKIN' IMPORTANT ON THESE PROCESSORS and STOCK HSF's!!
Be very careful to familiarize yourself with the push-pin arrangement. The instructions say that "you'll hear a click" when the pin is locked to the motherboard bottom. You may hear a click, but it may not have locked itself. Either install the cooler on the CPU and board prior to installing in the case, or test each push-pin by pulling straight up on it. People have had problems with this, and then reported unreasonably high temperatures. The pins should be pushed in using a diagonal sequence -- first two opposite corners, then the other two.
Before you install the sink, lay down your Arctic Silver 5 or whatever you plan to use. ONce again -- these are $75 processors, but the extra 3C degree improvement in temperatures -- possibly more for these low-end CPUs -- is worth the $5 for some IC Diamond paste, and the patience spreading the muck on the bottom of the Intel sink and your (hopefully lapped) processor cap. Even without lapping, with 50% over-clocks, my temperatures as normalized for 90F room ambient, are still 17+C degrees below the INtel thermal spec for these processors. (But I used the diamond paste, and so if you choose not to do so, expect a 14C-below-intel-thermal-spec at 90F. )
I've yet to try a different multiplier for the 2180, and the 2140 is locked at 8. I'm guessing -- guessing that you can get to 3.0 Ghz easy for this processor using a 333 Mhz host frequency, and 1:1 with some DDR2-667 (CAS = 3) RAM. You should be able to do it right away -- im-mED-iately!! -- by setting the VCORE to exactly 1.3500V.
But first check to see what your BIOS monitor reports in the default settings' stock "Auto" mode. I'd bet money but for the transaction costs through this forum that it shows something like 1.347V, but maybe it varies. If it shows something lower, then pick a notch above what BIOS monitor reports. Otherwise, follow the guides here on over-clocking.
And -- yes -- "guessing." Remember I have the low-end and the high-end of the 21x0, and your 2160 is in the middle. I defer to my comments above speculating about the manufacturing process, because some of the conclusion came from comparing these chips.
IF you choose to run DDR2-800 or higher, I'm thinking you'd be better off with the DDR2-800. At host-frequency 333 Mhz and FSB 1,333 Mhz, you can run the DDR2-800 (if you buy Crucials or something similar) at 835 Mhz with a 4:5 ratio.
Does that get you started?