If I can hit the hot-key easily with my left-hand, I use the hot-keys. Since that usually means holding down the Ctrl or Alt key with another key, that means nothing farther than the C key and only as high as the A. Copy and Select All are the most commonly used commands for me. If I have my right hand on the mouse selecting text, usually my left hand is resting on the keyboard waiting to type something else, so it's close to the keys. If I'm using the mouse and my left hand isn't particularly near the keyboard, I use the right-click menu. Too much moving back and forth to use hot-keys with my right hand.