Disorders that aren't disorders

Page 6 - Seeking answers? Join the AnandTech community: where nearly half-a-million members share solutions and discuss the latest tech.
Oct 25, 2006
11,036
11
91
Wow, amazing. Sounds like those drugs are prescribed for ALL KINDS OF SHIT, primarily for an endless cash deficiency disorder suffered by doctors and pharmaceutical companies.

Wow. It's almost like psychological disorders and physiological disorders have a biological basis and medications that control the major neurotransmitters in brain function can be used to treat a wide range of disorders stemming from a imbalance of those neurotransmitters.

Good god, it almost makes sense.
 

destrekor

Lifer
Nov 18, 2005
28,799
359
126
Wow. It's almost like psychological disorders and physiological disorders have a biological basis and medications that control the major neurotransmitters in brain function can be used to treat a wide range of disorders stemming from a imbalance of those neurotransmitters.

Good god, it almost makes sense.

:thumbsup:

Sometimes reformulations and re-purposing is done for money reasons, but most of these are actually re-purposed after other doctors and scientists have studied the effects and began to use them off-label due to demonstrated success.

Doses often change for different disorders, but there's a reason drugs can be both good and bad: ketamine is typically an analgesic, sometimes it's a highly hallucinogenic dissociative, and sometimes it can be used for cases of bi-polar disorder and other disorders that don't respond to other treatment. Dissociatives (established ones and new research chemicals that are derivatives) are also being studied, iirc, for other more severe disorders like schizophrenia and others.
 
Apr 17, 2005
13,465
3
81
Wow. It's almost like psychological disorders and physiological disorders have a biological basis and medications that control the major neurotransmitters in brain function can be used to treat a wide range of disorders stemming from a imbalance of those neurotransmitters.

Good god, it almost makes sense.

yup. And there is good evidence and science behind it.

Clonidine is one of those meds, originally used for blood pressure control as it is a centrally acting alpha 2 receptor agonist. It works by reducing sympathetic tone. The sympathetic system is the flight or fight response, and this is the same thing that is hyperactive in PTSD. ADHD was presumed to be similar, although new research shows that there is also issues with prefrontal regulation of attention.

But, like with a lot of psych illness, the pathophysiology is often understood by sort of "reverse engineering" efficacious meds and trying to understand how they work, e.g dopamine blockade in antipsychotics and how dopamine excess is involved in schizophrenia.