I think Windows is a little smarter now with that and remembers the actual monitors, so the location it's plugged in does not matter. When I switch my PC from home to work and vise versa it remembers my setup at both places even if they are not the same and I don't have to care about what monitor plugs where. Well as long as nobody messes with my monitors that is...
One thing Windows does that infuriates me though is that if you turn off a monitor it will completely shuffle all your stuff all over and mess up everything. This may partially be the fault of monitor manufacturers too. IMO they should have standby power to keep emulating the monitor so that Windows does not react in any way and thinks there is still a monitor th ere.
Another thing they need to fix - and Linux is guilty of this too, is where windows/dialogs open. It should always open on the monitor that the cursor is on, not randomly whereever it wants. Excell is horrible for this. You do a search and the search box ends up in the abyss completely off the charts instead of where you're working. worse is when you do in fact rearrange your monitors and now you have stuff opening in space that does not exist. Good luck trying to get to it now!