SP33Demon
Lifer
To investigate the matter, Anthony Rosenzweig and his team fed mice one of three diets for a 12-week period. Their method and findings are published in the Proceedings of the National Academies of Science.
The low carbohydrate-high protein (LCHP) contained 12 per cent carbohydrate, 43 per cent fat, 45 per cent protein and 0.15 per cent cholesterol. The standard mouse chow diet had for 65 per cent carbs, 15 per cent fat and 20 per cent protein. The ?typical Western? diet (WD) 43 had carbohydrate, 42 per cent fat, 15 per cent protein, and 0.15 per cent cholesterol.
The team found that the mice on the LCHP diet had gained less weight than the mice on the standard diet, but they had 15 per cent more aortic atherosclerosis ? the thickening of artery walls due to plaque formation ? and generated fewer new vessels in response to tissue ischemia. These changes could not be explained by changes in serum cholesterol, inflammatory mediators or infiltrates or oxidative stress.
By contrast, the WD mice group had 9 per cent more atherosclerosis than those on the standard chow.
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Upping your intake to 40-45% fat calories will put you at risk. Will you lose weight? Probably, but you will pay the price for it down the road.
One thing I wish they added to the study was another control group with 42/43/15 protein/carbs/fat to see what the effect of changing out carbs to protein had on plaque buildup in the arteries vs the standard chow. I doubt it would be that significant.