Yeah I know. I consider it 3 scenarios (mishandling of wild strains, mishandling of engineered strains, intentional release of manipulated strains), which are grossly cross-represented. I've only ever been reasonably interested in the first two, third being ridiculous unless it happens twice more (incident, coincidence, enemy action). I'm only willing to entertain the possibility of the second specifically because of a) lack of expertise in the field of virology, b) lack of transparency from the government overseeing the ... c) virology lab performing gain of function research on viruses (which if my memory serves, were coronaviruses) like a block away from the stated patient zero infection point. Some claim that a) is sufficient to dispel the possibility, but I'm skeptical because b) and c) walk and talk like a duck, respectively.
It's akin to a fire breaking out in NYC and spreading uncontrolled to a dozen nearby blocks, afterwards discovering that right nearby is a govt research lab which researches advanced incendiaries or rocket fuel or something, then being told 'no actually it was a shop selling sparklers on the corner' and everyone going 'HMM YES THAT SURE DOES MAKE MORE SENSE, DON'T FALL PREY TO CONSPIRACY THEORIES'.
You'll have to clarify what is meant by gain of function research that was occurring in Wuhan. Which specific experiments? Many of the reporting has confused where some of these research projects were done. Some of the experiments were actually conducted in the United States.
On top of that, one has to consider what they were doing. The primary researcher was interested in SARS-CoV-1 and very closely related bat coronaviruses. She studied those bat coronaviruses because they were closely related to SARS-CoV-1 and was important to understanding the origins of CoV-1. The logic behind her work made sense. But then why would she (or others) choose a strain of virus not closely related to SARS-CoV-1, that has unknown biology, and decided, yeah of all the coronaviruses I could work on, it will be that one!
Here's a family tree that contains many of bat coronaviruses, CoV-1, and CoV-2. If you are a researcher, wouldn't you work on Bat-SL-CoV because they are all closely related to CoV-1? Why would you choose, say the Zhejiang, Kenya, or Bulgaria species (clade 1 and 2)?
Even if you decide to work on a new virus. You can't just conjure up tools and techniques to study the virus overnight. You have to build the capacity to detect the virus, you have build methods to cultivate the virus in the lab. Even after all that work, developing techniques to build the virus can take several years. And somehow you have to find time to work on all this, while still working on other projects and publishing them. It does not add up.
My issue with this is the 'known precursor'. You have to accept that the actual precursor to the COVID-19 alpha strain had to be genetically very similar to the precursor yes? Which means whatever it jumped from (pangolin, penguin, bat, whatever) was already just on the verge of COVID-19, correct? So that actual, real precursor existed whether it was on a slab of dead whatever in a meat market or in a test tube next door. So based on that, why is it so insane to suggest it could have been from a novel sample in an actual research laboratory instead of a one in a million meat market sample? Why does the former make more sense than the latter?
I don't dispute the possibility that CoV-2 (or something super similar, e.g. <20 mutations) was sitting in a sample and accidentally got out. What I do dispute is that any idea of something more distantly related was being engineered/manipulated by WIV, and then escaped the lab. That's much of what the story in the OP proposes (and a few other conspiracy blog posts out there), that SARS-CoV-2 is the result of manipulations to RatG13 and it escaped. That makes no sense on the several levels I've written about.
And to reiterate a similar point, let's say you found the true precursor to SARS-CoV-2 in 2015. Why would you invest millions and years of work to work on something you have no confidence on will have any meaning on human health?
I don't know, many of the novel breakthroughs in science come precisely from looking for something other than what you expected. Maybe they were looking for something annihilating nearby bat populations? Maybe they were looking for a weaponized system to control murderous pangolins? It's really hard to define a negative, doubly so when there's a shroud of obfuscation over the whole ordeal (which frankly just breeds pessimism and conspiracy).
Do we even know the stated mission(s) of the virology lab? And not just the part the US was funding, the whole thing.
WIV clearly had their missions defined in the past, the original iteration was founded in the 1950's. China has been a major location for emergence of viruses of concern including SARS, Avian influenza, flaviviruses, and many others. It is also a major research institution in general, they support research of non-human virology fields. You can find papers from WIV in the 2000's where researchers were working on viruses from
crayfish and studying
bacteria.
Would you rather scientists study concerning viruses at the "source?" Or would you be comfortable loading Ebola, SARS, or smallpox samples into a plane or ship and moving them thousands of miles across the world?
And don't forget. Wuhan is the ninth most populous city in China. If SARS-CoV-2 emerged from Chicago or London (cities of similar size) would everyone be accusing virologists at Northwestern or the Imperial College of London? So much of certain people's fears have been built upon not knowing about Wuhan, realizing there's a research center named "virology," and jumping to some sort of nefarious connection. Yes, there's a woman there who works on coronaviruses. Ok, make the case then, show us why and how she was doing nefarious work at the same time, and had the capacity to do all these things.