Antibiotics that target mitochondria effectively eradicate cancer stem cells

[rudeguy]

Well, if researchers were smarter than they currently are = cancer cured.
For profit healthcare is awesome unless you are poor. Proof, 3rd world countries tend to be poor & can't treat a number of diseases that industrialized countries shrug at. Even here in the US, being poor straight up limits what you can do healthcare wise unless your insurance co pays for it. GL getting them to pay for truly experimental treatments that cost hundreds of thousands on a small % chance of working.

Is this close to home for you man? You seem really emotionally invested and maybe you have a resentment that is fogging up your view on things?

 

[uclaLabrat]

Cancer would be already a non-issue if today's researchers weren't dumbasses & biotech companies weren't for profit.

 

[DCal430]

It may be an effective treatment for some cancers, but I doubt all. Cancer is a very broad thing, and their are many different cancers. Not sure how it would be effective against all of them, without being effective at killing all of your healthy cells too.

 

[DCal430]

Read up on how cancer actually kills you.

There are many different cancers, each one can kill in a different way.

Example people with MM rarely have metastasis, but often die due to sepsis or organ failure from too much abnormal antibodies in their bloods. I know someone with Myeloma who died from sepsis, bacteria took advantage of his weaken immune system due to the cancer. He fought hard, but it couldn't make it.

People with parathyroid cancer also rarely have metastasis, but often die due to kidney failure as the parathyroid maintains kidney function.

People with Endocrine cancers can die from hormonal imbalance.


Each cancer is different, and and cause illness and death in different ways.

 

[Bock]

Is this close to home for you man? You seem really emotionally invested and maybe you have a resentment that is fogging up your view on things?

Not really. Almost went into that field, turns out the avg researcher has a ~130 iq. I expected it to be much higher since in finance, most of the guys I work with are in the 130's also.

 

[zinfamous]

Well, if researchers were smarter than they currently are = cancer cured.

what the ever-loving dickball does this mean?

 

[Brainonska511]

what the ever-loving dickball does this mean?

Tin foil hat is too tight.

 

[DCal430]

Wait, Bock, do you think Chemo kills people and not cancer?

 

[Crono]

Not really. Almost went into that field, turns out the avg researcher has a ~130 iq. I expected it to be much higher since in finance, most of the guys I work with are in the 130's also.

Translation for us dummies: "my field is smarter than your field, nana nana boo boo"

If the research process is broken, go fix it. Or at least propose something useful.

 

[Hayabusa Rider]

Wait, Bock, do you think Chemo kills people and not cancer?

He thinks that because we aren't omniscient someone stupid is to blame. Don't ask him about vaccines.

 

[Bock]

Wait, Bock, do you think Chemo kills people and not cancer?

Chemo drugs can kill if ineffectively administered. A taxol shot to the brain/heart should do the trick. Cancer kills via complications such organ failure, loss in rbc, infections, etc etc.

Someone earlier said there's many different cancers with 1000's of causes; however they all have one thing in common, unregulated cell division. Taxol is effective on the cell division part.

 

[Brainonska511]

Chemo drugs can kill if ineffectively administered. A taxol shot to the brain/heart should do the trick. Cancer kills via complications such organ failure, loss in rbc, infections, etc etc.

Someone earlier said there's many different cancers with 1000's of causes; however they all have one thing in common, unregulated cell division. Taxol is effective on the cell division part.

And why they have unregulated cell division and disabled cell death can differ greatly between various cancer types - if you make a targeted drug for one cancer type, it's entirely possible it won't work on another because a different mechanism in play. Despite what you seem to believe, research is actually quite difficult and can be quite expensive, just to figure out the basic biology. Add another couple layers as you move onto drug discovery, drug delivery, drug testing... But please, stand over our shoulder and tell us in your 'expert' opinion what we're all doing wrong in our research, because you clearly know better.

 

[Jeff7]

And why they have unregulated cell division and disabled cell death can differ greatly between various cancer types - if you make a targeted drug for one cancer type, it's entirely possible it won't work on another because a different mechanism in play. Despite what you seem to believe, research is actually quite difficult and can be quite expensive, just to figure out the basic biology. Add another couple layers as you move onto drug discovery, drug delivery, drug testing... But please, stand over our shoulder and tell us in your 'expert' opinion what we're all doing wrong in our research, because you clearly know better.

You were already told: Just make the cells stop doing that.


Have you tried a sternly-worded letter to the cells, or perhaps had a discussion with them about their life choices? Problem solved.

 

[Brainonska511]

You were already told: Just make the cells stop doing that.


Have you tried a sternly-worded letter to the cells, or perhaps had a discussion with them about their life choices? Problem solved.

I haven't tried the letter yet, but through thorough testing, I have found that yelling at them produces no effect.

 

[Bock]

And why they have unregulated cell division and disabled cell death can differ greatly between various cancer types - if you make a targeted drug for one cancer type, it's entirely possible it won't work on another because a different mechanism in play. Despite what you seem to believe, research is actually quite difficult and can be quite expensive, just to figure out the basic biology. Add another couple layers as you move onto drug discovery, drug delivery, drug testing... But please, stand over our shoulder and tell us in your 'expert' opinion what we're all doing wrong in our research, because you clearly know better.

Why they do that isn't as important as stopping it.
A good analogy is, why does a mass murderer kill, you can waste time on that nonsense while people die or you can get much better at stopping the killer before they end up killing everyone. Let's say this mass murderer has a habit of killing food producers {farmers}, if this killer goes unchecked, eventually society will starve to death.

 

[Brainonska511]

Why they do that isn't as important as stopping it.
A good analogy is, why does a mass murderer kill, you can waste time on that nonsense while people die or you can get much better at stopping the killer before they end up killing everyone. Let's say this mass murderer has a habit of killing food producers {farmers}, if this killer goes unchecked, eventually society will starve to death.

LOL. Why they go haywire and stay that way is intrinsically linked in how to stop them. How can you stop them if you don't know how to target only the cancer cells. If you know the exact problem, you can look for drugs that target those specific proteins causing the cells to cancerous, instead of also hitting all those healthy cells you need to live.

And your analogy stinks. Stick with what you know, which clearly isn't anything related to biology.

 

[Anonemous]

Interesting...

 

[OverVolt]

Its just aging is the reality of it. As cell lines run their course and die out since they have a limited number of times they can replicate the remaining cell lines pick up the slack but it burns them out. Hence why you decline very quickly at the end of life.

 

[Capt Caveman]

Chemo drugs can kill if ineffectively administered. A taxol shot to the brain/heart should do the trick. Cancer kills via complications such organ failure, loss in rbc, infections, etc etc.

Someone earlier said there's many different cancers with 1000's of causes; however they all have one thing in common, unregulated cell division. Taxol is effective on the cell division part.

:biggrin:

 

[Bock]

And your analogy stinks.

No, it's exacty spot on.

 

[DCal430]

You know what is interesting is some chemo drugs are now being used to treat conditions other than cancer.

 

[OverVolt]

You know what is interesting is some chemo drugs are now being used to treat conditions other than cancer.

Well that will decrease life expectancy.

 

[MrRamon]

I wonder what was learned from Henrietta Lacks's cancer cells.

 

[DCal430]

Well that will decrease life expectancy.

Some of these conditions are terminal if not treated, and chemo is the best treatment for them.

 

[Bock]

Another way I think about it, I can run around with a scalpel & physically cure everyone from deadly cancer tumors. While the cancer didn't kill them, the brute surgery got them. Let's say I had a advanced robotic surgical tech that can make that possible w/o killing the patient. Also add in tech that can detect cancerous masses smaller than a 1cm.

Would cancer still be an issue that killed millions per year?

That's why I say researchers are dumbasses & biotech shouldn't be for profit.