It is good to keep the cards spread out but with a creative labs sound card, try to stay away from the fifth PCI slot below the AGP slot. For some reason the creative sound blaster live and audigy behave oddly on some motherboards in the fifth slot. The problems that occur is usually a total system freeze with an annoying loud beep comming from the speakers. I had to talk to alot of people before figuring out the cause of this problem with my old system.