I don't know for sure, but I think that the front-panel audio header on the motherboard might even work when using PCI sound cards. Easy enough to find out, eh? 🙂
Also, you will like the quality of the Inwin. The cables are very burly. One note: the LED starts out green and switches to orange, which looks like some sort of negative thing, but orange means it's switched to USB Hi-Speed mode, which is what you want (Hi-Speed > Full-Speed). I recommend you do NOT install the drivers or the disk-icon utility, they're resource hogs.