First thing is to check white balance, exposure, and contrast. Then move the detail zoom to the area that you want to be sharp, and then zoom photo to 1:1 as it will show what your final image will be. Then play around with sharpening (20~40), radius (0.5~1.6), detail (default 25 but IMHO it pending noise), and masking (any amount, but the more the worst it get). Then play around with noise reduction, luminance, detail, contrast, and colour. Then recheck highlights shadows, whites, and blacks. Then check clarity, vibrant, and saturation. Then spot removal, filter, etc...