Runs fast as snot on our new computers in the office (thank you Dell Outlet! :laugh: ). New start menu is great, integrated search is fantastic, especially as it integrates with Outlook 2007. Shadow copies of local files, complete pc backup are great to have and I've freed up most of one of my monitors with outlook & messenger gadgets. We've gotten a little use out of Windows Meeting Space, but I don't see it replacing WebEx or Live Meeting.

Mobile Device Center is a big improvement over Activesync.
As for home use, I really love the new Photo Gallery and can't wait to replace my Media Center box with a Vista machine, especially once DCT-equipped machines start coming out and down in price. Also can't wait to see what Fiji will bring to WMC. Standby/Hibernate on my (fairly old) notebook seems faster than XP. Explorer refinements, thumbnails and favorite folders on the left pane are welcome improvements.
One thing I don't like are the changes to how VPN connections are handled. I connect to a couple dozen different VPNs regularly, and the lack of a flyout window on the Start menu slows me down. However, adding a shortcut to Network Connections is almost as quick. There are also way too many windows involved when creating/connecting to connections through "Connect To." UAC doesn't bother me.