Are you running Malwarebytes free or a paid tier? If you are running Malwarebytes free, Windows Defender should be absolutely fine.
As far as paid Malwarebytes is concerned, I've been running Malwarebytes standard (I have several lifetime licenses from way back when they were still a thing) as my solitary and primary anti-virus for probably 8-9 years now and have had absolutely no problems whatsoever.
From 2010 until about 2015, I used to run a secondary antivirus as well (the free versions of Avast, then later Bitdefender and finally Kaspersky after Bitdefender free went away for a while), but eventually eliminated them all as they were beginning to have serious conflicts with the newer versions of Malwarebytes standard that even establishing exceptions couldn't resolve.
As long as you aren't actively seeking out dangerous websites, you should be good against drive-by infections in either circumstance.